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UniProtKB/Swiss-Prot entry Q9ZL14

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IMDH_HELPJ
Primary accession number Q9ZL14
Secondary accession numbers None
Integrated into Swiss-Prot on January 11, 2001
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 65)
Name and origin of the protein
Protein name Inosine-5'-monophosphate dehydrogenase
Synonyms IMP dehydrogenase
IMPDH
IMPD
EC 1.1.1.205
Gene name
Name: guaB
OrderedLocusNames: jhp_0768
From
Helicobacter pylori J99 (Campylobacter pylori J99) [TaxID: 85963] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/16495; PubMed=9923682 [NCBI, ExPASy, EBI, Israel, Japan]
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D., Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori.";
Nature 397:176-180(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE001439; AAD06347.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H71890; H71890.
RefSeq NP_223486.1; -.
3D structure databases
HSSP P49058; 1EEP. [HSSP ENTRY / PDB]
ModBase Q9ZL14.
Enzyme and pathway databases
BioCyc HPYL85963:JHP0768-MON; -.
Ontologies
GO
GO:0003938; Molecular function: IMP dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0030955; Molecular function: potassium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006177; Biological process: GMP biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013785; Aldolase_TIM.
IPR000644; Cysta_beta_synth_core.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR005990; IMP_DHase.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
PANTHER PTHR11911:SF6; IMP_DH_GMPRtase; 1.
Pfam PF00571; CBS; 1.
PF00478; IMPDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000130; IMPDH; 1.
SMART SM00116; CBS; 2.
SMART graphical view of domain structure.
TIGRFAMs TIGR01302; IMP_dehydrog; 1.
PROSITE PS51371; CBS; 2.
PS00487; IMP_DH_GMP_RED; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 890128; -.
GenomeReviews AE001439_GR; jhp_0768.
KEGG hpj:jhp0768; -.
NMPDR fig|85963.1.peg.764; -.
Phylogenomic databases
HOGENOM Q9ZL14; -.
Genome annotation databases
CMR Q9ZL14; jhp_0768.
Other
ProtoNet Q9ZL14.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
CBS domain; Complete proteome; GMP biosynthesis; Metal-binding; NAD; Oxidoreductase; Potassium; Purine biosynthesis; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   481  481     Inosine-5'-monophosphate dehydrogenase. PRO_0000093699
DOMAIN   92   148  57     CBS 1. 
DOMAIN   152   209  58     CBS 2. 
NP_BIND   225   246  22     NAD (By similarity). 
ACT_SITE   300   300        Thioimidate intermediate (By similarity). 
METAL   295   295        Potassium; via carbonyl oxygen (By similarity). 
METAL   297   297        Potassium; via carbonyl oxygen (By similarity). 
BINDING   333   333        IMP (By similarity). 
BINDING   380   380        IMP (By similarity). 
Sequence information
Length: 481 AA [This is the length of the unprocessed precursor] Molecular weight: 51689 Da [This is the MW of the unprocessed precursor] CRC64: 688262DCD14EFDAB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRILQRALTF EDVLMVPRKS SVLPKDVSLK SRLTKNIGLN IPFISAAMDT VTEHKTAIAM 

        70         80         90        100        110        120 
ARLGGIGIVH KNMDIQTQVK EITKVKKSES GVINDPIFIH AHRTLADAKV ITDNYKISGV 

       130        140        150        160        170        180 
PVVDDKGLLI GILTNRDVRF ETDLSKKVGD VMTKMPLVTA HVGISLDEAS DLMHKHKIEK 

       190        200        210        220        230        240 
LPIVDKDNVL KGLITIKDIQ KRIEYPEANK DDFGRLRVGA AIGVGQLDRA EMLVKAGVDA 

       250        260        270        280        290        300 
LVLDSAHGHS ANILHTLEEI KKSLVVDVIV GNVVTKEATS DLISAGADAV KVGIGPGSIC 

       310        320        330        340        350        360 
TTRIVAGVGM PQVSAIDNCV EVASKFDIPV IADGGIRYSG DVAKALALGA SSVMIGSLLA 

       370        380        390        400        410        420 
GTEESPGDFM IYQGRQYKSY RGMGSIGAMT KGSSDRYFQE GVASEKLVPE GIEGRVPYRG 

       430        440        450        460        470        480 
KVSDMIFQLV GGVRSSMGYQ GAKNILELYQ NAEFVEITSA GLKESHVHGV DITKEAPNYY 


G
Q9ZL14 in FASTA format

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