[1]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=9615452 [NCBI, ExPASy, EBI, Israel, Japan] Bradley R.D., Adkins R.M., Honeycutt R.L., McDonald J.H.; "Nucleotide polymorphism at the alcohol dehydrogenase locus of pocket gophers, genus Geomys."; Mol. Biol. Evol. 15:709-717(1998).

Comments

CATALYTIC ACTIVITY: An alcohol + NAD⁺ = an aldehyde or ketone + NADH.
COFACTOR: Binds 2 zinc ions per subunit (By similarity).
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF044730; AAC98959.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P00327; 1HEU. [HSSP ENTRY / SWISS-3DIMAGE / PDB]

SMR

Q9Z2M2; 1-374, 2-375.

ModBase

Q9Z2M2.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004022;	Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0008270;	Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.

PANTHER

PTHR11695; ADH_Sf_Zn; 1.

Pfam

PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.

PROSITE

PS00059; ADH_ZINC; 1.

ProtoNet

Q9Z2M2.

Phylogenomic databases

HOVERGEN

Q9Z2M2; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 375`	`374`	`Alcohol dehydrogenase 1.`	`PRO_0000254949`
`METAL`	`47 47`		`Zinc 1; catalytic (By similarity).`
`METAL`	`68 68`		`Zinc 1; catalytic (By similarity).`
`METAL`	`98 98`		`Zinc 2 (By similarity).`
`METAL`	`101 101`		`Zinc 2 (By similarity).`
`METAL`	`104 104`		`Zinc 2 (By similarity).`
`METAL`	`112 112`		`Zinc 2 (By similarity).`
`METAL`	`175 175`		`Zinc 1; catalytic (By similarity).`

Sequence information

Length: 375 AA [This is the length of the unprocessed precursor]

Molecular weight: 39841 Da [This is the MW of the unprocessed precursor]

CRC64: 6A01A35C159C1122 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSTAGKVIKC RAAVLWEKNK PFSIEEVEVA PPKAYEVRIK IVATGICRSD DHVVNGSIIT 

        70         80         90        100        110        120 
PLPAILGHEA GGIVESIGEG VTTVKPGDKV IPLFVPQCGK CRACKHPESN LCTHGDLGRA 

       130        140        150        160        170        180 
QGTLMDGTSR FTCKGKPIHH FLGVTTFSEY TVVSEISVTK IDAASPLEKV CLIGCGFSTG 

       190        200        210        220        230        240 
YGSAVKVGKV ARGSICACVW SGRVGLSAII GCKAAGAARI IAVDINKDKF AKAKELGATE 

       250        260        270        280        290        300 
CVNPQDYDKP IYEVLQEMTD GGVDFSFEVI GRLDTKVSAL MCCQESHGVS VIVGVPPNAQ 

       310        320        330        340        350        360 
SLTIDPKVLL SGRSWKGAVF GGYKGKDDVP KLVADFMAKK FPLEPLITNV FPLAKINEGF 

       370 
DLLRAGKSIR TVLTF

Q9Z2M2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools