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UniProtKB/Swiss-Prot entry Q9Z0X4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PDE3A_MOUSE
Primary accession number Q9Z0X4
Secondary accession numbers None
Integrated into Swiss-Prot on May 10, 2004
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 52)
Name and origin of the protein
Protein name cGMP-inhibited 3',5'-cyclic phosphodiesterase A
Synonyms EC 3.1.4.17
Cyclic GMP-inhibited phosphodiesterase A
CGI-PDE A
Gene name
Name: Pde3a
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J;
TISSUE=Ovary;
Shitsukawa K., Andersen C.B., Richard F.J., Conti M.;
"Characterization of cGMP-inhibited phosphodiesterase (PDE3A) expressed in mouse oocyte.";
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
[2]
 PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1073/pnas.0609836104; PubMed=17242355 [NCBI, ExPASy, EBI, Israel, Japan]
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF099187; AAD16300.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_061249.1; -.
UniGene Mm.103728
3D structure databases
HSSP Q08499; 1MKD. [HSSP ENTRY / PDB]
SMR Q9Z0X4; 677-1049.
ModBase Q9Z0X4.
PTM databases
PhosphoSite Q9Z0X4; -.
Organism-specific databases
MGI MGI:1860764; Pde3a.
Gene expression databases
ArrayExpress Q9Z0X4; -.
CleanEx MM_PDE3A; -.
Ontologies
GO
GO:0005626; Cellular component: insoluble fraction (inferred from direct assay from MGI).
GO:0016020; Cellular component: membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005625; Cellular component: soluble fraction (inferred from direct assay from MGI).
GO:0004115; Molecular function: 3',5'-cyclic-AMP phosphodiesterase activity (inferred from direct assay from MGI).
GO:0001556; Biological process: oocyte maturation (inferred from direct assay from MGI).
GO:0040020; Biological process: regulation of meiosis (inferred from direct assay from MGI).
GO:0042493; Biological process: response to drug (inferred from direct assay from MGI).
GO:0007165; Biological process: signal transduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR003607; Met-dep_phosphohydro_HD.
IPR002073; PDEase.
Graphical view of domain structure.
Pfam PF00233; PDEase_I; 1.
Pfam graphical view of domain structure.
SMART SM00471; HDc; 1.
SMART graphical view of domain structure.
PROSITE PS00126; PDEASE_I; 1.
Proteomics databases
PRIDE Q9Z0X4; -.
Genome annotation databases
Ensembl ENSMUSG00000041741; Mus musculus. [Contig view]
GeneID 54611; -.
KEGG mmu:54611; -.
Phylogenomic databases
HOGENOM Q9Z0X4; -.
HOVERGEN Q9Z0X4; -.
Other
NextBio 311416; -.
SOURCE Pde3a; Mus musculus.
ProtoNet Q9Z0X4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
cGMP; Hydrolase; Membrane; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   1141  1141     cGMP-inhibited 3',5'-cyclic phosphodiesterase A. PRO_0000198800
MOD_RES   310    310        Phosphoserine (By similarity). 
MOD_RES   425    425        Phosphoserine (By similarity). 
MOD_RES   437    437        Phosphothreonine (By similarity). 
MOD_RES   495    495        Phosphoserine. 
Sequence information
Length: 1141 AA [This is the length of the unprocessed precursor] Molecular weight: 124513 Da [This is the MW of the unprocessed precursor] CRC64: 3D9ACCFF928219D8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAVRGEAAQD LAKPGLGGAS PARVARGNHR HRGESSPSPR GSGCCWRALA LQPLRRSPQL 

        70         80         90        100        110        120 
SSALCAGSLS VLLALLVRLV GGEVGGELEK SQEAAAEEEE EEGARGGVFP GPRGGAPGGG 

       130        140        150        160        170        180 
AQLSPWLQPA ALLFSLLCAF FWMGLCLLRA GVRLPLAVAL LAACCAGEAL VQLSLGVGDG 

       190        200        210        220        230        240 
RLLSLPAAGV LLSCLGGATW LVLRLRLGVL MVAWTSVLRT VALVSLERFK VAWRPYLAYL 

       250        260        270        280        290        300 
AAVLGLLLAR YAEQILPQCS GPAPPRERFG SQLSARTKEE IPGWKRRRRS SSVVAGEMSG 

       310        320        330        340        350        360 
CSGKSHRRTS LPCIPREQLM GHSEWDHKRG PRGSQSGTSI TVDIAVMGEA HGLITDLLAD 

       370        380        390        400        410        420 
PSLPPNVCTS LRAVSNLLST QLTFQAIHKP RVNPTVTFSE NYTCSDSEEG LEKDKQAISK 

       430        440        450        460        470        480 
RLRRSLPPGL LRRVSSTWTT TTSATGLPTL EPAPVRRDRS ASIKPHEAPS PSAVNPDSWN 

       490        500        510        520        530        540 
APGLTTLTKS RSFTSSYAVS AANHVKAKKQ NRPGGLAKIS PVPSPSSSPP QGSPASSPVS 

       550        560        570        580        590        600 
NSASQQFPES PEVTIKRGPG SHRALTYTQS APDLSPQIPP PSVICSSCGR PYSQGNPADG 

       610        620        630        640        650        660 
PSERSGPAML KPNRTDDTSQ VTSDYETNNN SDSSDILQNE EEAECQREPQ RKASACGTYT 

       670        680        690        700        710        720 
SQTMIFLDKP ILAPEPLVMD NLDSIMDQLN TWNFPIFDLM ENIGRKCGRI LSQVSYRLFE 

       730        740        750        760        770        780 
DMGLFEAFKI PVREFMNYFH ALEIGYRDIP YHNRIHATDV LHAVWYLTTQ PIPGLPSVIG 

       790        800        810        820        830        840 
DHGSASDSDS DSGFTHGHMG YVFSKMYHVP DDKYGCLSGN IPALELMALY VAAAMHDYDH 

       850        860        870        880        890        900 
PGRTNAFLVA TSAPQAVLYN DRSVLENHHA AAAWNLFMSR PEYNFLVNLD HVEFKHFRFL 

       910        920        930        940        950        960 
VIEAILATDL KKHFDFVAKF NAKVNDDVGI DWTNENDRLL VCQMCIKLAD INGPAKCKEL 

       970        980        990       1000       1010       1020 
HLRWTEGIAS EFYEQGDEEA SLGLPISPFM DRSAPQLANL QESFISHIVG PLCHSYDSAG 

      1030       1040       1050       1060       1070       1080 
LMPGKWVDDS DDSGDTDDPE EEEEEAETPH EDEACESSIA PRKKSFKRRR IYCQITQHLL 

      1090       1100       1110       1120       1130       1140 
QNHMMWKKVI EEEQCLSGTE NQSLDQVPLQ HPSEQIQAIK EEEEEKGKPR AEETLAPQPD 


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Q9Z0X4 in FASTA format

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