[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Landrace X Pietrain; PubMed=12030927 [NCBI, ExPASy, EBI, Israel, Japan] Jacobs K., Mattheeuws M., Van Poucke M., Van Zeveren A., Peelman L.J.; "Characterization of the porcine FABGL gene."; Anim. Genet. 33:220-223(2002).

Comments

FUNCTION: Uses estradiol as its preferred substrate (By similarity).
CATALYTIC ACTIVITY: Estradiol-17-beta + NAD(P)⁺ = estrone + NAD(P)H.
CATALYTIC ACTIVITY: Testosterone + NAD⁺ = androst-4-ene-3,17-dione + NADH.
PATHWAY: Steroid biosynthesis; estrogen biosynthesis .
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF146398; AAD44802.2; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P97852; 1GZ6. [HSSP ENTRY / PDB]

ModBase

Q9XT00.

Ontologies

GO:0005488;	Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004303;	Molecular function: estradiol 17-beta-dehydrogenase activity (inferred from electronic annotation from EC).
GO:0050327;	Molecular function: testosterone 17-beta-dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006694;	Biological process: steroid biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PRINTS

PR00081; GDHRDH.
PR00080; SDRFAMILY.

PROSITE

PS00061; ADH_SHORT; 1.

Phylogenomic databases

HOVERGEN

Q9XT00; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Lipid synthesis; NAD; Oxidoreductase; Steroid biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 259`	`259`	`Estradiol 17-beta-dehydrogenase 8.`	`PRO_0000054600`
`NP_BIND`	`13 37`	`25`	`NAD (By similarity).`
`ACT_SITE`	`167 167`		`Proton acceptor (By similarity).`
`BINDING`	`154 154`		`Substrate (By similarity).`

Sequence information

Length: 259 AA [This is the length of the unprocessed precursor]

Molecular weight: 26622 Da [This is the MW of the unprocessed precursor]

CRC64: E8A357BCCD26DD1C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MASQLRLRSA LALVTGAGSG IGRAVSVRLA AEGAAVAACD LDGAAAQETV QLLGGPGSEK 

        70         80         90        100        110        120 
GAPSGPMAAF QADVSEAETA RRLLEQVQAY FFRPPSVVVS CAGITRDEFL LRMSEDDWDK 

       130        140        150        160        170        180 
VIAVNLKGIF LVTQAAAQAL VSSGCPGSII NISSIIGKVG NMGQTNYAAS KAGVIGLTQA 

       190        200        210        220        230        240 
VARELGRYRI RCNSVLPGFI KTPMAQKVPQ KVLDKVVGMI PMGHLGGPPD VADVVAFLAS 

       250 
EDSGYITGAS VEVTGGLFM

Q9XT00 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools