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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, AND INTERACTION WITH GRIA2 AND GRIA3.
DOI=10.1016/S0896-6273(00)80568-1; PubMed=9768844 [NCBI, ExPASy, EBI, Israel, Japan]
Srivastava S.,
Osten P.,
Vilim F.S.,
Khatri L.,
Inman G.,
States B.,
Daly C.,
DeSouza S.,
Abagyan R.,
Valtschanoff J.G.,
Weinberg R.J.,
Ziff E.B.;
"Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP.";
Neuron 21:581-591(1998).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE, AND INTERACTION WITH EFNB1 AND EFNB3.
TISSUE=Hippocampus;
DOI=10.1016/S0896-6273(00)80706-0; PubMed=10197531 [NCBI, ExPASy, EBI, Israel, Japan]
Brueckner K.,
Pablo Labrador J.,
Scheiffele P.,
Herb A.,
Seeburg P.H.,
Klein R.;
"EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains.";
Neuron 22:511-524(1999).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND SUBCELLULAR LOCATION.
TISSUE=Hippocampus;
PubMed=10436050 [NCBI, ExPASy, EBI, Israel, Japan]
Dong H.,
Zhang P.,
Song I.,
Petralia R.S.,
Liao D.,
Huganir R.L.;
"Characterization of the glutamate receptor-interacting proteins GRIP1 and GRIP2.";
J. Neurosci. 19:6930-6941(1999).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, AND INTERACTION WITH GRIA2 AND GRIA3.
PubMed=10414981 [NCBI, ExPASy, EBI, Israel, Japan]
Wyszynski M.,
Valtschanoff J.G.,
Naisbitt S.,
Dunah A.W.,
Kim E.,
Standaert D.G.,
Weinberg R.,
Sheng M.;
"Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo.";
J. Neurosci. 19:6528-6537(1999).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND PALMITOYLATION.
PubMed=11978826 [NCBI, ExPASy, EBI, Israel, Japan]
DeSouza S.,
Fu J.,
States B.A.,
Ziff E.B.;
"Differential palmitoylation directs the AMPA receptor-binding protein ABP to spines or to intracellular clusters.";
J. Neurosci. 22:3493-3503(2002).
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[6]
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INTERACTION WITH GRIPAP1.
DOI=10.1016/S0896-6273(00)81198-8; PubMed=10896157 [NCBI, ExPASy, EBI, Israel, Japan]
Ye B.,
Liao D.,
Zhang X.,
Zhang P.,
Dong H.,
Huganir R.L.;
"GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex.";
Neuron 26:603-617(2000).
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[7]
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INTERACTION WITH CSGP4, AND DOMAIN.
DOI=10.1074/jbc.M210010200; PubMed=12458226 [NCBI, ExPASy, EBI, Israel, Japan]
Stegmueller J.,
Werner H.,
Nave K.-A.,
Trotter J.;
"The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling.";
J. Biol. Chem. 278:3590-3598(2003).
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- FUNCTION: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.
- SUBUNIT: Interacts with the C-terminal tail of PRLHR (By similarity). Interacts with EFNB1, EFNB3, GRIA2, GRIA3, CSGP4 and GRIPAP1. Can form homomultimers and heteromultimers with GRIP1.
- INTERACTION:
Self; NbExp=1; IntAct=EBI-936068, EBI-936068;
P19491:Gria2; NbExp=4; IntAct=EBI-936068, EBI-77718;
P97879:Grip1; NbExp=1; IntAct=EBI-936068, EBI-936113;
- SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Isoform 1 and isoform 3 were found in synaptic plasma membrane and postsynaptic density. Isoform 3 was also found in dendrites where it was associated with microtubules, endoplasmic reticulum and dendritic spines. Isoform 2 was found at excitatory synapses and also at non-synaptic membranes and within intracellular compartments. Isoform 4 was exclusively membrane associated.
- ALTERNATIVE PRODUCTS:
4 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Synonyms | ABP-L, ABP-L/GRIP2 |
| Isoform ID | Q9WTW1-2 |
| Features which should be applied to build the isoform sequence: VSP_009761. |
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| Name | 4 |
| Synonyms | pABP-L |
| Isoform ID | Q9WTW1-4 |
| Note: Palmitoylated on Cys-11. |
| Features which should be applied to build the isoform sequence: VSP_009759. |
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- TISSUE SPECIFICITY: Brain specific. Isoform 1 is expressed in the olfactory bulb, cortex and hippocampus and was also expressed at lower levels in thalamus, cerebellum and spinal cord. Isoform 3 is expressed in pyramidal cells of cortex and hippocampus, striatum, thalamus, hypothalamus, stellate cells of cerebellum, and brainstem. Isoform 2 and isoform 4 are expressed in cortex, hippocampus, thalamus, cerebellum, brainstem and spinal cord. In hippocampal neurons isoform 4 is found abundantly in spine structures. Isoform 2 is abundant in the cell body and also found in dendritic shafts.
- DEVELOPMENTAL STAGE: Isoform 1 expression was relatively low early in development and increased postnatally, reaching a peak at P14. Isoform 3 is detected at low levels prior to P9, whereupon its expression increases, with the highest levels in the adult.
- DOMAIN: PDZ 5 mediates the C-terminal binding of GRIA2 and GRIA3. PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1. PDZ 7 mediates interaction with CSPG4.
- PTM: Palmitoylation of isoform 4 mediates membrane location.
- SIMILARITY: Belongs to the GRIP2 family.
- SIMILARITY: Contains 7 PDZ (DHR) domains.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 1043 AA [This is the length of the unprocessed precursor] |
Molecular weight: 112488 Da [This is the MW of the unprocessed precursor] |
CRC64: C463C36ADC459A3C [This is a checksum on the sequence] |
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10 20 30 40 50 60
MLAVSLKWRL GVVRRRPKDD GPYSKGGKDT AGTDGALVCR RQSIPEEFRG ITMVELIKRE
70 80 90 100 110 120
GSTLGLTISG GTDKDGKPRV SNLRPGGLAA RSDLLNVGDY IRSVNGIRLT RLRHDEIITL
130 140 150 160 170 180
LKNVGERVVL EVEYELPPPA PENNPRIISK TVDVSLYKEG NSFGFVLRGG AHEDLHKSRP
190 200 210 220 230 240
LVLTYVRPGG PADREGSLKV GDRLLSIDGI PLHGASHATA IATLQQCSHE ALFQVEYDVA
250 260 270 280 290 300
TPDTVANASG PLVVEIAKTP GSALGISLTT GSHRNKPAIT IDRIKPASVV DRSGALHAGD
310 320 330 340 350 360
HILAIDGTST EHCSLVEATK LLASVTEKVR LEILPAPQSR RPLKPPEAVR IQRSEQLHHW
370 380 390 400 410 420
DPCVPSCHSP RPSHCRAPTW APGGQDQSRS VSSTPFSSPT MNPAFPCANA STLPRGPMSP
430 440 450 460 470 480
RTTAGRRRQR RKEHRSSLSL ASSTVGPGGQ IVHTETTEVV LCGDPLSGFG LQLQGGIFAT
490 500 510 520 530 540
ETLSSPPLVR FIEPDSPAER CGLLQVGDRV LAINGIATED GTMEEANQLL RDAALARKVV
550 560 570 580 590 600
LEIEFDVAES VIPSSGTFHV KLPKRRGVEL GITISSASRK RGEPLIISDI KKGSVAHRTG
610 620 630 640 650 660
TLEPGDKLLA IDNIRLDHCP MEYAVQILRQ CEDLVKLKIR KDEDNSDEQE SSGAVSYTVE
670 680 690 700 710 720
LKRYGGPLGI TISGTEEPFD PIIISGLTKR GLAERTGAIH VGDRILAINS VSLKGRPLSE
730 740 750 760 770 780
AIHLLQVAGE TVTLKIKKQL DRPLLPRQSG SLSEASDVDE DPPEALKGGL LTTHFSPAVP
790 800 810 820 830 840
SVDSAVESWG SSATEGGFGG SGSYTPQVAV RSVTPQEWRS SRLKSSPPPL EPRRTSYTPG
850 860 870 880 890 900
PTDESFPEEE EGDWEPPMSP APGPAREEGF WRVLGEALED LESCGQSELL RELEASIMTG
910 920 930 940 950 960
TVQSVAVDGR PGSRPWRRSR EVGTSPEDLQ ELLLPTPLEM HRVTLHKDPV RNDFGFSVSD
970 980 990 1000 1010 1020
GLLEKGVYVH TVRIDGPAQH GGLQPFDRLL QVNHVRTRDF DCCLAVPLLA EAGDILELVV
1030 1040
SRNPLAQSRR TPGAPGPSSP QMI
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Q9WTW1 in FASTA format |
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