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UniProtKB/Swiss-Prot entry Q9VXY0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP4S3_DROME
Primary accession number Q9VXY0
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 61)
Name and origin of the protein
Protein name Probable cytochrome P450 4s3
Synonyms EC 1.14.-.-
CYPIVS3
Gene name
Name: Cyp4s3
ORFNames: CG9081
From
Drosophila melanogaster (Fruit fly) [TaxID: 7227] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2]
GENOME REANNOTATION.
PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan]
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE014298; AAF48426.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_573003.2; -.
UniGene Dm.19710
3D structure databases
HSSP P14779; 1JPZ. [HSSP ENTRY / PDB]
ModBase Q9VXY0.
Protein-protein interaction databases
DIP DIP:19604N; -.
IntAct Q9VXY0; -.
Enzyme and pathway databases
BioCyc DMEL-XXX-02:DMEL-XXX-02-001936-MON; -.
Organism-specific databases
FlyBase FBgn0030615; Cyp4s3.
Gene expression databases
ArrayExpress Q9VXY0; -.
GermOnline CG9081; Drosophila melanogaster.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS Q9VXY0.
Genome annotation databases
Ensembl CG9081; Drosophila melanogaster. [Contig view]
GeneID 32444; -.
KEGG dme:Dmel_CG9081; -.
NMPDR fig|7227.3.peg.17896; -.
Phylogenomic databases
HOGENOM Q9VXY0; -.
Other
ProtoNet Q9VXY0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   495  495     Probable cytochrome P450 4s3. PRO_0000051848
METAL   436   436        Iron (heme axial ligand) (By similarity). 
BINDING   307   307        Heme (covalent; via 1 link) (By similarity). 
Sequence information
Length: 495 AA [This is the length of the unprocessed precursor] Molecular weight: 57189 Da [This is the MW of the unprocessed precursor] CRC64: 4AE96B1BFF502891 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSTLALVAFV LWAAFLRYLP KILNFLRLQR FAKTLPGPTI GELIANVKKG EILNWLKELR 

        70         80         90        100        110        120 
EKHGPVFRIW FGKDLMVMFT DPEDIKQLLG NNQLLTKSRN YELLEPWLGK GLLTNGGESW 

       130        140        150        160        170        180 
HRRRKLLTPG FHFRILSEFK EPMEENCRIL VRRLRTKANG ESFDIYPYIT LFALDAICET 

       190        200        210        220        230        240 
AMGIKKHAQL QSDSEYVQAV QSICRVMHKQ SFSFWQRLNV FFKHTKPGKE REAALKVLHD 

       250        260        270        280        290        300 
ETNRVIRLRR EQLIQERNEW KPEAEQDDVG AKRRLAFLDM LLLTQMEGGA ELSDTDIREE 

       310        320        330        340        350        360 
VDTFMFEGHD TTSSAIAFAL SLLSKNPDVQ QRAFEEASEL EGREKESMPY LEAVIKETLR 

       370        380        390        400        410        420 
IYPSVPFFSR KVLEDLEVGK LTVPKGASIS CLIYMLHRDP KNFPDPERFD PDRFLVNEKQ 

       430        440        450        460        470        480 
MHPFAFAAFS AGPRNCIGQK FAMLELKTSL AMLLRSYRFL PDKDHQPKPL AELVTKSGNG 

       490 
IRLRILPRDE NGTTA 

Q9VXY0 in FASTA format

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