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UniProtKB/Swiss-Prot entry Q9UHA7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IL1F6_HUMAN
Primary accession number Q9UHA7
Secondary accession numbers Q53SR7 Q5BLR4 Q7RTZ8
Integrated into Swiss-Prot on November 8, 2002
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 60)
Name and origin of the protein
Protein name Interleukin-1 family member 6
Synonyms IL-1F6
Interleukin-1 epsilon
IL-1 epsilon
FIL1 epsilon
Gene name
Name: IL1F6
Synonyms: FIL1E, IL1E
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1074/jbc.275.2.1169; PubMed=10625660 [NCBI, ExPASy, EBI, Israel, Japan]
Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E., Sims J.E.;
"Four new members expand the IL-1 superfamily.";
J. Biol. Chem. 275:1169-1175(2000).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.2002.6751; PubMed=11991722 [NCBI, ExPASy, EBI, Israel, Japan]
Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K.;
"A sequence-based map of the nine genes of the human interleukin-1 cluster.";
Genomics 79:718-725(2002).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-12; THR-63 AND ARG-134.
SeattleSNPs program for genomic applications;
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NITRATION [LARGE SCALE ANALYSIS] AT TYR-96, AND MASS SPECTROMETRY.
TISSUE=Pituitary adenoma;
DOI=10.1016/j.ab.2006.05.024; PubMed=16777052 [NCBI, ExPASy, EBI, Israel, Japan]
Zhan X., Desiderio D.M.;
"Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry.";
Anal. Biochem. 354:279-289(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF201831; AAF25211.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BN000002; CAD29875.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY944686; AAX20113.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC016724; AAY14988.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC107042; AAI07043.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC107043; AAI07044.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_055255.1; -.
UniGene Hs.278910
3D structure databases
HSSP P01584; 1L2H. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
ModBase Q9UHA7.
PTM databases
PhosphoSite Q9UHA7; -.
Organism-specific databases
H-InvDB HIX0029830; -.
HGNC HGNC:15562; IL1F6.
GenAtlas IL1F6.
MIM 605509; gene. [NCBI / EBI]
PharmGKB PA38389; -.
GeneCards Q9UHA7.
Gene expression databases
ArrayExpress Q9UHA7; -.
CleanEx HS_IL1F6; -.
GermOnline ENSG00000136694; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (non-traceable author statement from UniProtKB).
GO:0005149; Molecular function: interleukin-1 receptor binding (non-traceable author statement from UniProtKB).
GO:0006955; Biological process: immune response (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR000975; Interleukin_1.
IPR003294; InterleukinIL1AB.
IPR003296; InterleukinIL1B.
Graphical view of domain structure.
Pfam PF00340; IL1; 1.
Pfam graphical view of domain structure.
PRINTS PR00264; INTERLEUKIN1.
PR01359; INTRLEUKIN1B.
PR01357; INTRLEUKN1AB.
ProDom PD002536; Interleukin_1; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00125; IL1; 1.
SMART graphical view of domain structure.
PROSITE PS00253; INTERLEUKIN_1; FALSE_NEG.
BLOCKS Q9UHA7.
ProtoNet Q9UHA7.
Genome annotation databases
Ensembl ENSG00000136694; Homo sapiens. [Contig view]
GeneID 27179; -.
KEGG hsa:27179; -.
Phylogenomic databases
HOGENOM Q9UHA7; -.
HOVERGEN Q9UHA7; -.
Other
NextBio 50004; -.
SOURCE IL1F6; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytokine; Nitration; Polymorphism; Secreted.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   158  158     Interleukin-1 family member 6. PRO_0000153644
MOD_RES   96    96        Nitrated tyrosine. 
VARIANT   12    12  1     Q -> R (in dbSNP:rs895497 [NCBI]). VAR_024504 
VARIANT   63    63  1     I -> T (in dbSNP:rs28938798 [NCBI]). VAR_025055 
VARIANT   134   134  1     G -> R (in dbSNP:rs28947175 [NCBI]). VAR_025056 
Sequence information
Length: 158 AA [This is the length of the unprocessed precursor] Molecular weight: 17684 Da [This is the MW of the unprocessed precursor] CRC64: 469AC84306B0E280 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEKALKIDTP QQGSIQDINH RVWVLQDQTL IAVPRKDRMS PVTIALISCR HVETLEKDRG 

        70         80         90        100        110        120 
NPIYLGLNGL NLCLMCAKVG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES 

       130        140        150 
VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF 

Q9UHA7 in FASTA format

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