[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=ATCC 9937 / LMG 1404 / NCIB 8084; PubMed=11111029 [NCBI, ExPASy, EBI, Israel, Japan] Felder M., Gupta A., Verma V., Kumar A., Qazi G.N., Cullum J.; "The pyrroloquinoline quinone synthesis genes of Gluconobacter oxydans."; FEMS Microbiol. Lett. 193:231-236(2000).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=621H; DOI=10.1038/nbt1062; PubMed=15665824 [NCBI, ExPASy, EBI, Israel, Japan] Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.; "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans."; Nat. Biotechnol. 23:195-200(2005).

Comments

FUNCTION: Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ (By similarity).
CATALYTIC ACTIVITY: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O₂ = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H₂O₂ + 2 H₂O.
PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis .
SIMILARITY: Belongs to the pqqC family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ277117; CAB83199.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
CP000009; AAW60757.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_191413.1; -.

3D structure databases

ModBase

Q9L3B2.

Enzyme and pathway databases

BioCyc

GOXY290633:GOX0985-MON; -.

Ontologies

GO:0033732;	Molecular function: pyrroloquinoline-quinone synthase activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0018189;	Biological process: pyrroloquinoline quinone biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00654; -; 1.
PBIL [Tree]

InterPro

IPR016084; Haem_Oase-like_multi-hlx.
IPR011845; PQQ_synth_PqqC.
IPR004305; TENA/THI4/PQQ_synth_PqqC.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.910.10; Haem_Oase-like_multi-hlx; 1.

Pfam

PF03070; TENA_THI-4; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02111; PQQ_syn_pqqC; 1.

ProtoNet

Q9L3B2.

Genome annotation databases

GeneID

3250200; -.

GenomeReviews

CP000009_GR; GOX0985.

KEGG

gox:GOX0985; -.

NMPDR

fig|290633.1.peg.958; -.

Phylogenomic databases

HOGENOM

Q9L3B2; -.

Genome annotation databases

CMR

Q9L3B2; GOX0985.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Oxidoreductase; PQQ biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 239`	`239`	`Pyrroloquinoline-quinone synthase.`	`PRO_0000219978`
`CONFLICT`	`69 69`		`A -> D (in Ref. 1; CAB83199).`
`CONFLICT`	`88 89`		`GT -> EP (in Ref. 1; CAB83199).`

Sequence information

Length: 239 AA [This is the length of the unprocessed precursor]

Molecular weight: 27293 Da [This is the MW of the unprocessed precursor]

CRC64: 708C883BED29C7F2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTLLTPDQLE AQLRQIGAER YHNRHPFHRK LHDGKLDKAQ VQAWALNRYY YQARIPAKDA 

        70         80         90        100        110        120 
TLLARLPTAE LRREWRRRIE DHDGTEPGTG GVARWLMLTD GLGLDRDYVE SLDGLLPATR 

       130        140        150        160        170        180 
FSVDAYVNFV RDQSILAAIA SSLTELFSPT IISERVSGML RHYDFVSEKT LAYFTPRLTQ 

       190        200        210        220        230 
APRDSDFALA YVREKARTPE QQKEVLGALE FKCSVLWTML DALDYAYVEG HIPPGAFVP

Q9L3B2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools