ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q9KLB8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name PH4H_VIBCH
Primary accession number Q9KLB8
Secondary accession numbers None
Integrated into Swiss-Prot on April 16, 2002
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 50)
Name and origin of the protein
Protein name Phenylalanine-4-hydroxylase
Synonyms PAH
EC 1.14.16.1
Phe-4-monooxygenase
Gene name
Name: phhA
OrderedLocusNames: VC_A0828
From
Vibrio cholerae [TaxID: 666] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 39315 / El Tor Inaba N16961 / Serotype O1;
DOI=10.1038/35020000; PubMed=10952301 [NCBI, ExPASy, EBI, Israel, Japan]
Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.";
Nature 406:477-483(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE003853; AAF96726.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D82413; D82413.
RefSeq NP_233214.1; -.
3D structure databases
HSSP P30967; 1LTU. [HSSP ENTRY / PDB]
ModBase Q9KLB8.
Ontologies
GO
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0004505; Molecular function: phenylalanine 4-monooxygenase activity (inferred from electronic annotation from InterPro).
GO:0006559; Biological process: L-phenylalanine catabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001273; Aaa_hydroxylase.
IPR005960; Phe-4-hydroxylase_mono.
Graphical view of domain structure.
Gene3D G3DSA:1.10.800.10; Aaa_hydroxylase; 1.
PANTHER PTHR11473; Aaa_hydroxylase; 1.
Pfam PF00351; Biopterin_H; 1.
Pfam graphical view of domain structure.
PRINTS PR00372; FYWHYDRXLASE.
ProDom PD002559; Aaa_hydroxylase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01267; Phe4hydrox_mono; 1.
PROSITE PS00367; BIOPTERIN_HYDROXYL; 1.
ProtoNet Q9KLB8.
Genome annotation databases
GeneID 2612712; -.
GenomeReviews AE003853_GR; VC_A0828.
KEGG vch:VCA0828; -.
TIGR VC_A0828; -.
Phylogenomic databases
HOGENOM Q9KLB8; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Phenylalanine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   289  289     Phenylalanine-4-hydroxylase. PRO_0000205558
METAL   144   144        Iron (Potential). 
METAL   149   149        Iron (Potential). 
METAL   189   189        Iron (Potential). 
Sequence information
Length: 289 AA [This is the length of the unprocessed precursor] Molecular weight: 33445 Da [This is the MW of the unprocessed precursor] CRC64: 2D68B31C6E31D521 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSKIPLAVRI GLGRLNVTNL LRSRAMTQYH SKPVSEHGHI DWDQDEHAVW HELITRQQEV 

        70         80         90        100        110        120 
VKTRACQAYL DGLNMLNLPT DRLPQLPEIN RVLQRETGWQ VEPVPALISF DRFFALLADK 

       130        140        150        160        170        180 
KFPVATFLRR REEFDYLQEP DFFHEVYGHC AMLTHPDFAA FTHVYGQLGA KATPKERSYL 

       190        200        210        220        230        240 
ARLYWFTVEF GLVQEQGQTK IYGGGILSSP GETLYASEST IPKREPFDIM QVLRTPYRID 

       250        260        270        280 
IMQPIYYVLP DLSQLYQLSQ RDVMALVWQA MQDGLLPPLF QPKEQQHAG
Q9KLB8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ca flag CBR Canada Mirror sites: Australia Brazil China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!