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UniProtKB/Swiss-Prot entry Q9HTE3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FADH_PSEAE
Primary accession number Q9HTE3
Secondary accession numbers None
Integrated into Swiss-Prot on May 15, 2007
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 48)
Name and origin of the protein
Protein name Glutathione-independent formaldehyde dehydrogenase
Synonyms FALDH
FDH
EC 1.2.1.46
Gene name
Name: fdhA
OrderedLocusNames: PA5421
From
Pseudomonas aeruginosa [TaxID: 287] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
DOI=10.1038/35023079; PubMed=10984043 [NCBI, ExPASy, EBI, Israel, Japan]
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.";
Nature 406:959-964(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE004091; AAG08806.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E82969; E82969.
RefSeq NP_254108.1; -.
3D structure databases
HSSP P46154; 1KOL. [HSSP ENTRY / PDB]
SMR Q9HTE3; 3-398.
ModBase Q9HTE3.
Enzyme and pathway databases
BioCyc PAER208964:PA5421-MON; -.
Organism-specific databases
PseudoCAP PA5421; -.
Ontologies
GO
GO:0018467; Molecular function: formaldehyde dehydrogenase activity (inferred from electronic annotation from EC).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
IPR014184; HCHO_DHase_non_GSH.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR02819; fdhA_non_GSH; 1.
PROSITE PS00059; ADH_ZINC; 1.
ProtoNet Q9HTE3.
Genome annotation databases
GeneID 880053; -.
GenomeReviews AE004091_GR; PA5421.
KEGG pae:PA5421; -.
Phylogenomic databases
HOGENOM Q9HTE3; -.
Genome annotation databases
CMR Q9HTE3; PA5421.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   399  398     Glutathione-independent formaldehyde dehydrogenase. PRO_0000287742
REGION   172   338  167     Cofactor-binding. 
METAL   47    47        Zinc 1; catalytic (By similarity). 
METAL   68    68        Zinc 1; catalytic (By similarity). 
METAL   98    98        Zinc 2 (By similarity). 
METAL   101   101        Zinc 2 (By similarity). 
METAL   104   104        Zinc 2 (By similarity). 
METAL   112   112        Zinc 2 (By similarity). 
METAL   177   177        Zinc 1; catalytic (By similarity). 
Sequence information
Length: 399 AA [This is the length of the unprocessed precursor] Molecular weight: 42008 Da [This is the MW of the unprocessed precursor] CRC64: FE1FBAE68A90C9FC [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSGNRGVVYL GPGKVEVQNI PYPKMQDPQG RQIDHGVILR VVSTNICGSD QHMVRGRTTA 

        70         80         90        100        110        120 
PEGLVLGHEI TGEVVEIGRG VETMKIGDLV SVPFNVACGH CRTCKEQHTG VCLTVNPARA 

       130        140        150        160        170        180 
GGAYGYVDMG GWVGGQAEYV LVPYADFNLL KLPNREAAME KIRDLTCLSD ILPTGYHGAV 

       190        200        210        220        230        240 
TAGVGPGSTV YIAGAGPVGL AAAASARLLG AAVVIVGDVN PTRLAHAKKQ GFEIADLSKD 

       250        260        270        280        290        300 
TPLHEQIAAL LGEPEVDCAV DAVGFEARGH GHSGSQQEAP ATVLNSLMGI TRVAGKIGIP 

       310        320        330        340        350        360 
GLYVTEDPGA VDAAAKHGAL SIRFGLGWAK SHSFHTGQTP VMKYNRQLMQ AIMWDRIKIA 

       370        380        390 
DIVGVEVITL DDAPKGYGEF DAGVPKKFVI DPHNLFRAA
Q9HTE3 in FASTA format

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