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UniProtKB/Swiss-Prot entry Q9HH99


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name P5CR_METAC
Primary accession number Q9HH99
Secondary accession numbers None
Integrated into Swiss-Prot on August 30, 2002
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 46)
Name and origin of the protein
Protein name Pyrroline-5-carboxylate reductase
Synonyms P5C reductase
P5CR
EC 1.5.1.2
Gene name
Name: proC
OrderedLocusNames: MA_4102
From
Methanosarcina acetivorans [TaxID: 2214] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
PubMed=11844777 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang J.K., White A.K., Kuettner H.C., Boccazzi P., Metcalf W.W.;
"Directed mutagenesis and plasmid-based complementation in the methanogenic archaeon Methanosarcina acetivorans C2A demonstrated by genetic analysis of proline biosynthesis.";
J. Bacteriol. 184:1449-1454(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
DOI=10.1101/gr.223902; PubMed=11932238 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P., McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.;
"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.";
Genome Res. 12:532-542(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF305580; AAG22033.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE010299; AAM07450.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_618970.1; -.
3D structure databases
ModBase Q9HH99.
Enzyme and pathway databases
BioCyc MACE188937:MA4102-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004735; Molecular function: pyrroline-5-carboxylate reductase activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006561; Biological process: proline biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR016040; NAD(P)-bd.
IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11645; P5CR; 1.
Pfam PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000193; Pyrrol-5-carb_rd; 1.
TIGRFAMs TIGR00112; proC; 1.
PROSITE PS00521; P5CR; 1.
ProtoNet Q9HH99.
Genome annotation databases
GeneID 1475996; -.
GenomeReviews AE010299_GR; MA_4102.
KEGG mac:MA4102; -.
NMPDR fig|188937.1.peg.3996; -.
Phylogenomic databases
HOGENOM Q9HH99; -.
Genome annotation databases
CMR Q9HH99; MA_4102.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   270  270     Pyrroline-5-carboxylate reductase. PRO_0000187312
Sequence information
Length: 270 AA [This is the length of the unprocessed precursor] Molecular weight: 27943 Da [This is the MW of the unprocessed precursor] CRC64: 50EC656AFC10B1CF [This is a checksum on the sequence]
        10         20         30         40         50         60 
MENQKIGFIG AGKMGSALMQ GTIKAGIVTP ENIGASDVYE PFLKDLQAKL GIRVSTDNAV 

        70         80         90        100        110        120 
IVRESDILIL AVKPQTLSSV LSNLKNEITS EKLVISIAAG VPLSTYEDAL LEGTRVVRVM 

       130        140        150        160        170        180 
PNIAATVSEA ASGIAPGKNA TPEDLKAALE IFSAVGTAVQ VPESLMDAVT GLSGSGPAFI 

       190        200        210        220        230        240 
FPVIEAMADG AVLEGMDRKS ALTLAAQTVL GAAKMALETG MHPGELKDMV TSPAGTTIQG 

       250        260        270 
IHSLEEAGIR AAFMNAVIRA SERSKELGKK 

Q9HH99 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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