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UniProtKB/Swiss-Prot entry Q9H0R8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GBRL1_HUMAN
Primary accession number Q9H0R8
Secondary accession number Q6FIE6
Integrated into Swiss-Prot on March 1, 2004
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 55)
Name and origin of the protein
Protein name Gamma-aminobutyric acid receptor-associated protein-like 1
Synonyms GABA(A) receptor-associated protein-like 1
Glandular epithelial cell protein 1
GEC-1
Early estrogen-regulated protein
Gene name
Name: GABARAPL1
Synonyms: GEC1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Placenta;
DOI=10.1006/bbrc.2001.4908; PubMed=11374880 [NCBI, ExPASy, EBI, Israel, Japan]
Vernier-Magnin S., Muller S., Sallot M., Radom J., Musard J.-F., Adami P., Dulieu P., Remy-Martin J.-P., Jouvenot M., Fraichard A.;
"A novel early estrogen-regulated gene gec1 encodes a protein related to GABARAP.";
Biochem. Biophys. Res. Commun. 284:118-125(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
DOI=10.1006/geno.2001.6555; PubMed=11414770 [NCBI, ExPASy, EBI, Israel, Japan]
Xin Y., Yu L., Chen Z., Zheng L., Fu Q., Jiang J., Zhang P., Gong R., Zhao S.;
"Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein.";
Genomics 74:408-413(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.GR1547R; PubMed=11230166 [NCBI, ExPASy, EBI, Israel, Japan]
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.;
"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.";
Genome Res. 11:422-435(2001).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, and Colon;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
FUNCTION, AND INTERACTION WITH OPRK1.
DOI=10.1074/jbc.M509805200; PubMed=16431922 [NCBI, ExPASy, EBI, Israel, Japan]
Chen C., Li J.-G., Chen Y., Huang P., Wang Y., Liu-Chen L.-Y.;
"GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor.";
J. Biol. Chem. 281:7983-7993(2006).
[8]
X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 3-111.
Structural genomics consortium (SGC);
"Crystal structure of human gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAP1).";
Submitted (SEP-2007) to the PDB data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF287012; AAK55962.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF087847; AAK20399.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136676; CAB66611.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR533480; CAG38511.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471094; EAW96164.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC009309; AAH09309.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC028315; AAH28315.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_113600.1; -.
UniGene Hs.524250
3D structure databases
PDB
2R2Q; X-ray; 1.65 A; A/B=3-111.[ExPASy / RCSB / EBI]
PDBsum 2R2Q; -.
ModBase Q9H0R8.
Protein-protein interaction databases
IntAct Q9H0R8; -.
PTM databases
PhosphoSite Q9H0R8; -.
Organism-specific databases
H-InvDB HIX0010424; -.
HIX0036758; -.
HGNC HGNC:4068; GABARAPL1.
GenAtlas GABARAPL1.
MIM 607420; gene. [NCBI / EBI]
PharmGKB PA28481; -.
GeneCards Q9H0R8.
Gene expression databases
ArrayExpress Q9H0R8; -.
CleanEx HS_GABARAPL1; -.
GermOnline ENSG00000139112; Homo sapiens.
Ontologies
GO
GO:0005776; Cellular component: autophagic vacuole (inferred from direct assay from MGI).
GO:0005783; Cellular component: endoplasmic reticulum (inferred from electronic annotation from UniProtKB-KW).
GO:0005794; Cellular component: Golgi apparatus (inferred from electronic annotation from UniProtKB-KW).
GO:0016020; Cellular component: membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005874; Cellular component: microtubule (inferred from electronic annotation from UniProtKB-KW).
GO:0048487; Molecular function: beta-tubulin binding (inferred from sequence or structural similarity from UniProtKB).
GO:0050811; Molecular function: GABA receptor binding (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR004241; MAP1_LC3.
Graphical view of domain structure.
PANTHER PTHR10969; MAP1_LC3; 1.
Pfam PF02991; MAP1_LC3; 1.
Pfam graphical view of domain structure.
ProtoNet Q9H0R8.
Genome annotation databases
Ensembl ENSG00000139112; Homo sapiens. [Contig view]
GeneID 23710; -.
KEGG hsa:23710; -.
Phylogenomic databases
HOGENOM Q9H0R8; -.
HOVERGEN Q9H0R8; -.
Other
NextBio 46611; -.
SOURCE GABARAPL1; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cytoplasm; Endoplasmic reticulum; Golgi apparatus; Membrane; Microtubule.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   117  117     Gamma-aminobutyric acid receptor-associated protein-like 1. PRO_0000212369
REGION   1    22  22     Interaction with beta-tubulin (By similarity). 
REGION   36    68  33     Interaction with GABRG2 (By similarity). 
HELIX   4     8  5      
HELIX   11    24  14      
STRAND   28    35  8      
STRAND   48    52  5      
HELIX   57    67  11      
STRAND   77    80  4      
HELIX   91    98  8      
STRAND   105   110  6      
Sequence information
Length: 117 AA [This is the length of the unprocessed precursor] Molecular weight: 14044 Da [This is the MW of the unprocessed precursor] CRC64: 7F56E345255F564B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL VPSDLTVGQF 

        70         80         90        100        110 
YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE EDYFLYVAYS DESVYGK 

Q9H0R8 in FASTA format

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