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UniProtKB/Swiss-Prot entry Q9GL27

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name BRAC_CANFA
Primary accession number Q9GL27
Secondary accession numbers None
Integrated into Swiss-Prot on April 26, 2005
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 33)
Name and origin of the protein
Protein name Brachyury protein
Synonym T protein
Gene name
Name: T
From
Canis familiaris (Dog) [TaxID: 9615] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT MET-63.
DOI=10.1007/s003350010253; PubMed=11252170 [NCBI, ExPASy, EBI, Israel, Japan]
Haworth K.E., Putt W., Cattanach B., Breen M., Binns M., Lingaas F., Edwards Y.H.;
"Canine homolog of the T-box transcription factor T; failure of the protein to bind to its DNA target leads to a short-tail phenotype.";
Mamm. Genome 12:212-218(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ245513; CAC10530.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001003092.1; -.
UniGene Cfa.3518
3D structure databases
HSSP P24781; 1XBR. [HSSP ENTRY / PDB]
SMR Q9GL27; 41-224.
ModBase Q9GL27.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from InterPro).
GO:0003700; Molecular function: transcription factor activity (inferred from electronic annotation from InterPro).
GO:0007275; Biological process: multicellular organismal development (inferred from electronic annotation from UniProtKB-KW).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR002070; TF_Brachyury.
IPR001699; TF_T-box.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.820; TF_T-box; 1.
PANTHER PTHR11267; TF_T-box; 1.
Pfam PF00907; T-box; 1.
Pfam graphical view of domain structure.
PRINTS PR00938; BRACHYURY.
PR00937; TBOX.
SMART SM00425; TBOX; 1.
SMART graphical view of domain structure.
PROSITE PS01283; TBOX_1; 1.
PS01264; TBOX_2; 1.
PS50252; TBOX_3; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q9GL27.
Genome annotation databases
Ensembl ENSCAFG00000000807; Canis familiaris. [Contig view]
GeneID 403653; -.
KEGG cfa:403653; -.
Phylogenomic databases
HOVERGEN Q9GL27; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Activator; Developmental protein; DNA-binding; Nucleus; Polymorphism; Transcription; Transcription regulation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
CHAIN   1   435  435     Brachyury protein. PRO_0000184413
DNA_BIND   51   219  169     T-box. 
VARIANT   63    63  1     I -> M (in a bob-tailed dog; alters the ability of the protein to bind to its consensus DNA target). 
Sequence information
Length: 435 AA [This is the length of the unprocessed precursor] Molecular weight: 47148 Da [This is the MW of the unprocessed precursor] CRC64: CDCDB4A53A395AE2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSSPGAESAG KSLQYRVDHL LSAVESELQA GSEKGDPTER ELRVGLEDSE LWLRFKELTN 

        70         80         90        100        110        120 
EMIVTKNGRR MFPVLKVNVS GLDPNAMYSF LLDFVAADNH RWKYVNGEWV PGGKPEPQAP 

       130        140        150        160        170        180 
SCVYIHPDSP NFGAHWMKAP VSFSKVKLTN KLNGGGQIML NSLHKYEPRI HIVRVGGAQR 

       190        200        210        220        230        240 
MITSHCFPET QFIAVTAYQN EEITALKIKY NPFAKAFLDA KERSDHKDMM EEPGDSQQSG 

       250        260        270        280        290        300 
YSQWGWLIPG TSTLCPPATP HPQFGGPLSL PSTHGCERYP ALRNHRPSPY PSPYAHRNNS 

       310        320        330        340        350        360 
PTYSDNPSAC LSMLQSHDSW PSLGTPAHTS MLPMSHSAGP PTGSSQYPSL WSVSNGTITP 

       370        380        390        400        410        420 
GAQPAGMSNG LGAQFFRGSS AHGAPLGHAV PAPSASGSPL YEGAPTATDV PDSQYDASAQ 

       430 
ARLIASWTPV SPPSM
Q9GL27 in FASTA format

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