FUNCTION: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions (By similarity).
CATALYTIC ACTIVITY: NTP + H₂O = NDP + phosphate.
COFACTOR: Divalent cations (By similarity).
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the HAM1 NTPase family.

Copyright

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Cross-references

Sequence databases

EMBL

BA000019; BAB76787.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

AH2441; AH2441.

RefSeq

NP_489128.1; -.

3D structure databases

HSSP

Q57679; 1B78. [HSSP ENTRY / PDB]

ModBase

Q8YM52.

Enzyme and pathway databases

BioCyc

NSP103690:ALL5088-MON; -.

Ontologies

GO:0017111;	Molecular function: nucleoside-triphosphatase activity (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01405; -; 1.
PBIL [Tree]

InterPro

IPR002637; Ham1p_like.
Graphical view of domain structure.

PANTHER

PTHR11067; Ham1p_like; 1.

Pfam

PF01725; Ham1p_like; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00042; Ham1p_like; 1.

Genome annotation databases

GeneID

1108692; -.

GenomeReviews

BA000019_GR; all5088.

KEGG

ana:all5088; -.

NMPDR

fig|103690.1.peg.5395; -.

Phylogenomic databases

HOGENOM

Q8YM52; -.

Genome annotation databases

CMR

Q8YM52; all5088.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Hydrolase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 196`	`196`		`Nucleoside-triphosphatase.`	`PRO_0000178116`

Sequence information

Length: 196 AA [This is the length of the unprocessed precursor]

Molecular weight: 20883 Da [This is the MW of the unprocessed precursor]

CRC64: 1A85738A1CDE2558 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTKILIVATS NAGKLREMQA YLANTDWELT LKPTELEVEE TGDTFASNAC LKASEVAKAT 

        70         80         90        100        110        120 
GNWAIADDSG LQVDALNGLP GVYSARYGKT DGERISRLLK ELGSEVNRQA QFVCVVAIAS 

       130        140        150        160        170        180 
PDGAIALQAE GICRGEILHA PLGSGGFGYD PIFYVPEKQL TFAEMTPELK KSVSHRGKAF 

       190 
AALLPKMAAM LSSSAE

Q8YM52 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools