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UniProtKB/Swiss-Prot entry Q8NKC2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ENO12_SCHPO
Primary accession number Q8NKC2
Secondary accession number Q8TFF7
Integrated into Swiss-Prot on April 11, 2003
Sequence was last modified on April 11, 2003 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 44)
Name and origin of the protein
Protein name Enolase 1-2
Synonyms EC 4.2.1.11
2-phosphoglycerate dehydratase 1-2
2-phospho-D-glycerate hydro-lyase 1-2
Gene name
Name: eno102
Synonyms: eno1
ORFNames: SPBPB21E7.01c, SPBPB8B6.07c
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329671; CAD27913.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001018769.2; -.
3D structure databases
HSSP Q9NDH8; 1OEP. [HSSP ENTRY / PDB]
ModBase Q8NKC2.
Organism-specific databases
GeneDB_Spombe SPBPB21E7.01c; -.
Ontologies
GO
GO:0000015; Cellular component: phosphopyruvate hydratase complex (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004634; Molecular function: phosphopyruvate hydratase activity (inferred from electronic annotation from InterPro).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000941; Enolase.
Graphical view of domain structure.
PANTHER PTHR11902; Enolase; 1.
Pfam PF00113; Enolase_C; 1.
PF03952; Enolase_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001400; Enolase; 1.
PRINTS PR00148; ENOLASE.
ProDom PD000902; Enolase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01060; eno; 1.
PROSITE PS00164; ENOLASE; 1.
ProtoNet Q8NKC2.
Genome annotation databases
GeneID 3361181; -.
KEGG spo:SPBPB21E7.01c; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; Lyase; Magnesium; Metal-binding.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   440  440     Enolase 1-2. PRO_0000134059
REGION   373   376  4     Substrate binding (By similarity). 
ACT_SITE   212   212        Proton donor (By similarity). 
ACT_SITE   346   346        Proton acceptor (By similarity). 
METAL   247   247        Magnesium (By similarity). 
METAL   296   296        Magnesium (By similarity). 
METAL   321   321        Magnesium (By similarity). 
BINDING   160   160        Substrate (By similarity). 
BINDING   169   169        Substrate (By similarity). 
BINDING   296   296        Substrate (By similarity). 
BINDING   321   321        Substrate (By similarity). 
BINDING   397   397        Substrate (By similarity). 
Sequence information
Length: 440 AA [This is the length of the unprocessed precursor] Molecular weight: 47867 Da [This is the MW of the unprocessed precursor] CRC64: E59B1487C8C6B382 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTTIQKIYSR SIYDSRGNPT VEVELTTELG TFRSMVPSGA STGEWEAKEL RDNDKNKWGG 

        70         80         90        100        110        120 
KGVTIAVHNV NNIIGPALVK SDIKITDQRG IDEFMIKLDG TNDKSKLGAN SIVGVSMAVA 

       130        140        150        160        170        180 
RAAAAFLKIP LYEYIGKLAG SKTTECIPVP SFNVLNGGRH AGGDLAFQEF MIMPIKAPTF 

       190        200        210        220        230        240 
SEGLRWGSEV YHTLKALAKK KYGASAGNVG DEGGIAPDLT TAEEALDLVN EAIKEAGYDG 

       250        260        270        280        290        300 
KVKIGFDVAA SELYNGKLYD LDFKSEHPKP ENKLDYKKLY EKYSALIEKY PIVFIEDPFS 

       310        320        330        340        350        360 
EEDWGAFSYM SSKTKVEVIA DDLTVTNVKR LSKAIELKCA NALLVKINQI GSLSETIDAA 

       370        380        390        400        410        420 
NMAKKAGWGL MVSHRSGETD DSFIAHLAVG LEAGQMKSGA PCRSERLAKY NELLRIEDNL 

       430        440 
GDSAIYAGTR AADYIKSNTL 

Q8NKC2 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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