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UniProtKB/Swiss-Prot entry Q62904

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHB7_RAT
Primary accession number Q62904
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 66)
Name and origin of the protein
Protein name 3-keto-steroid reductase
Synonyms EC 1.1.1.270
Estradiol 17-beta-dehydrogenase 7
EC 1.1.1.62
17-beta-hydroxysteroid dehydrogenase 7
17-beta-HSD 7
PRL receptor-associated protein
PRAP
Gene name
Name: Hsd17b7
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 1-18.
STRAIN=Sprague-Dawley;
TISSUE=Corpus luteum;
DOI=10.1074/jbc.271.26.15602; PubMed=8663045 [NCBI, ExPASy, EBI, Israel, Japan]
Duan W.R., Linzer D.I.H., Gibori G.;
"Cloning and characterization of an ovarian-specific protein that associates with the short form of the prolactin receptor.";
J. Biol. Chem. 271:15602-15607(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U44803; AAC52623.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_058931.1; -.
UniGene Rn.7040
3D structure databases
ModBase Q62904.
Organism-specific databases
RGD 2837; Hsd17b7.
Gene expression databases
ArrayExpress Q62904; -.
GermOnline ENSRNOG00000002826; Rattus norvegicus.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0050576; Molecular function: 3-keto-steroid reductase activity (inferred from electronic annotation from EC).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004303; Molecular function: estradiol 17-beta-dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PRINTS PR00081; GDHRDH.
PROSITE PS00061; ADH_SHORT; FALSE_NEG.
ProtoNet Q62904.
Genome annotation databases
Ensembl ENSRNOG00000002826; Rattus norvegicus. [Contig view]
GeneID 29540; -.
KEGG rno:29540; -.
Phylogenomic databases
HOVERGEN Q62904; -.
Other
NextBio 609535; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Glycoprotein; Lipid synthesis; Membrane; NAD; NADP; Oxidoreductase; Steroid biosynthesis; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   334  334     3-keto-steroid reductase. PRO_0000054588
TOPO_DOM   1   229  229     Extracellular (Potential). 
TRANSMEM   230   250  21     Potential. 
TOPO_DOM   251   334  84     Cytoplasmic (Potential). 
NP_BIND   8    15  8     NAD (Potential). 
ACT_SITE   193   193        Proton acceptor (By similarity). 
BINDING   171   171        Substrate (By similarity). 
CARBOHYD   37    37        N-linked (GlcNAc...) (Potential). 
CARBOHYD   178   178        N-linked (GlcNAc...) (Potential). 
CARBOHYD   229   229        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 334 AA [This is the length of the unprocessed precursor] Molecular weight: 37372 Da [This is the MW of the unprocessed precursor] CRC64: 448B546CE8FCBFAC [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRKVVLITGA SSGIGLALCG RLLAEDDDLH LCLACRNLSK AGAVRDALLA SHPSAEVSIV 

        70         80         90        100        110        120 
QMDVSNLQSV VRGAEEVKRR FQRLDYLYLN AGIMPNPQLN LKAFFCGIFS RNVIHMFSTA 

       130        140        150        160        170        180 
EGLLTQNDKI TADGFQEVFE TNLFGHFILI RELEPLLCHS DNPSQLIWTS SRNAKKSNFS 

       190        200        210        220        230        240 
LEDIQHAKGQ EPYSSSKYAT DLLNVALNRN FNQKGLYSSV TCPGVVMTNL TYGILPPFVW 

       250        260        270        280        290        300 
TLLLPVIWLL RFFAHAFTVT PYNGAEALVW LFHQKPESLN PLTKYLSGTT GLGTNYVKGQ 

       310        320        330 
KMDVDEDTAE KFYKTLLELE KQVRITIQKS DHHS
Q62904 in FASTA format

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