NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 13543 / NRRL B-3784;
Dickins M.A., Dhawan T., Gunsalus R.P., Schroeder I., Cecchini G.;
"Cloning, sequencing, and expression of the succinate-ubiquinone oxidoreductase (SdhCDAB) operon from Paracoccus denitrificans.";
Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: Succinate + acceptor = fumarate + reduced acceptor.
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and an hydrophobic anchor protein.
SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U31902; AAA75177.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

T46880; T46880.

3D structure databases

HSSP

P10444; 1NEK. [HSSP ENTRY / PDB]

ModBase

Q59661.

Ontologies

GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0009055;	Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0050660;	Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0000104;	Molecular function: succinate dehydrogenase activity (inferred from electronic annotation from EC).
GO:0022900;	Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810;	Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
GO:0006099;	Biological process: tricarboxylic acid cycle (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR003953; FAD_bind2_N.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR003952; FRD_SDH_FAD_BS.
IPR004112; Fum_Rdtase/Succ_DHase_flav_C.
IPR011281; Succ_DHase_flav_su_fwd.
IPR014006; Succ_Dhase_frdA_Gneg.
Graphical view of domain structure.

Pfam

PF00890; FAD_binding_2; 1.
PF02910; Succ_DH_flav_C; 1.
Pfam graphical view of domain structure.

PRINTS

PR00368; FADPNR.

TIGRFAMs

TIGR01816; sdhA_forward; 1.
TIGR01812; sdhA_frdA_Gneg; 1.

PROSITE

PS00504; FRD_SDH_FAD_BINDING; 1.

ProtoNet

Q59661.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell inner membrane; Cell membrane; Electron transport; FAD; Flavoprotein; Membrane; Oxidoreductase; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 600`	`600`	`Succinate dehydrogenase flavoprotein subunit.`	`PRO_0000158655`
`NP_BIND`	`40 55`	`16`	`FAD (By similarity).`
`ACT_SITE`	`289 289`		`Proton acceptor (By similarity).`
`BINDING`	`245 245`		`Substrate (By similarity).`
`BINDING`	`257 257`		`Substrate (By similarity).`
`BINDING`	`356 356`		`Substrate (By similarity).`
`BINDING`	`401 401`		`Substrate (By similarity).`
`MOD_RES`	`48 48`		`Tele-8alpha-FAD histidine (By similarity).`

Sequence information

Length: 600 AA [This is the length of the unprocessed precursor]

Molecular weight: 65616 Da [This is the MW of the unprocessed precursor]

CRC64: E8446E4FB6D8F829 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAAYKYETHE YDVVVVGAGG AGLRATLGMA EQGLRTACVT KVFPTRSHTV AAQGGIAASL 

        70         80         90        100        110        120 
SNMGPDNWQW HMYDTVKGSD WLGDTDAMEY LAREAPKAVY ELEHYGVPFS RTEEGKIYQR 

       130        140        150        160        170        180 
PFGGHTTEFG EGPPVQRTCA AADRTGHAIL HTLYGQSLKE KAEFFIEYFA LDLIITDGAC 

       190        200        210        220        230        240 
TGVVCWKLDD GTIHVFNAKM VVLATGGYGR AYFSATSAHT CTGDGGGMVA RAGLPLQDME 

       250        260        270        280        290        300 
FVQFHPTGIY GSGCLITEGA RGEGGYLTNS EGERFMERYA PTYKDLASRD VVSRCITIEI 

       310        320        330        340        350        360 
REGRGVGPHK DHMHLNLMHL PPESLAERLP GISESAKIFA GVDVTREPIP ILPTVHYNMG 

       370        380        390        400        410        420 
GIPTNYWGEV LNPTQDNPDQ VFPGLMAVGE AGCASVHGAN RLGSNSLIDL VVFGRAAAIR 

       430        440        450        460        470        480 
AGQVIDREAQ IPTTNKEQVD KALDRFDRIR NADGSVSTAD LRLEMQRTMQ ADAAVFRTDK 

       490        500        510        520        530        540 
TLAEGVDKMR VIAGKLSDLK VTDRSLIWNS DLMETLELTN LMPNALATIV AAEARKESRG 

       550        560        570        580        590        600 
AHAHEDYPER DDANWRKHSL AWIEGNDVKL AYRPVHLEPL TRQDEGGIDL KKIAPKARVY

Q59661 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools