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UniProtKB/Swiss-Prot entry Q57991

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AK_METJA
Primary accession number Q57991
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 56)
Name and origin of the protein
Protein name Probable aspartokinase
Synonyms EC 2.7.2.4
Aspartate kinase
Gene name
OrderedLocusNames: MJ0571
From
Methanocaldococcus jannaschii (Methanococcus jannaschii) [TaxID: 2190] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanococci; Methanococcales; Methanocaldococcaceae; Methanocaldococcus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
PubMed=8688087 [NCBI, ExPASy, EBI, Israel, Japan]
Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii.";
Science 273:1058-1073(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L77117; AAB98565.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C64371; C64371.
RefSeq NP_247550.1; -.
3D structure databases
PDB
2HMF; X-ray; 2.70 A; A/B/C/D=2-470.[ExPASy / RCSB / EBI]
3C1M; X-ray; 2.30 A; A/B/C/D=1-473.[ExPASy / RCSB / EBI]
3C1N; X-ray; 2.72 A; A/B/C/D=1-473.[ExPASy / RCSB / EBI]
3C20; X-ray; 2.70 A; A/B=1-473.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 2HMF; -.
3C1M; -.
3C1N; -.
3C20; -.
ModBase Q57991.
Enzyme and pathway databases
BioCyc MJAN243232:MJ_0571-MON; -.
Ontologies
GO
GO:0016597; Molecular function: amino acid binding (inferred from electronic annotation from InterPro).
GO:0004072; Molecular function: aspartate kinase activity (inferred from electronic annotation from InterPro).
GO:0009088; Biological process: threonine biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002912; ACT_bd.
IPR001048; Asp/Glu/Uridylate_kinase.
IPR005260; Asp_kin_monofn.
IPR001341; Asp_kin_reg.
Graphical view of domain structure.
Gene3D G3DSA:3.40.1160.10; Aa_kinase; 1.
Pfam PF00696; AA_kinase; 1.
PF01842; ACT; 2.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00656; asp_kin_monofn; 1.
TIGR00657; asp_kinases; 1.
PROSITE PS00324; ASPARTOKINASE; 1.
ProtoNet Q57991.
Genome annotation databases
GeneID 1451436; -.
GenomeReviews L77117_GR; MJ0571.
KEGG mja:MJ0571; -.
NMPDR fig|243232.1.peg.587; -.
TIGR MJ0571; -.
Phylogenomic databases
HOGENOM Q57991; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Amino-acid biosynthesis; Complete proteome; Kinase; Repeat; Threonine biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   473  473     Probable aspartokinase. PRO_0000066688
DOMAIN   322   389  68     ACT 1. 
DOMAIN   408   473  66     ACT 2. 
STRAND   3     7  5      
HELIX   10    12  3      
HELIX   15    31  17      
STRAND   35    39  5      
HELIX   45    58  14      
HELIX   62    83  22      
HELIX   87   114  28      
HELIX   119   126  8      
HELIX   128   143  16      
STRAND   148   151  4      
TURN   153   157  5      
STRAND   158   160  3      
STRAND   169   172  4      
HELIX   174   183  10      
STRAND   187   196  10      
STRAND   202   204  3      
TURN   207   209  3      
HELIX   210   221  12      
STRAND   224   234  11      
STRAND   236   238  3      
TURN   240   242  3      
STRAND   250   253  4      
HELIX   254   262  9      
HELIX   270   272  3      
HELIX   273   278  6      
STRAND   283   287  5      
STRAND   296   300  5      
STRAND   306   308  3      
STRAND   311   325  15      
STRAND   327   329  3      
HELIX   331   344  14      
STRAND   349   354  6      
STRAND   361   365  5      
HELIX   370   381  12      
STRAND   395   410  16      
TURN   412   416  5      
HELIX   420   430  11      
STRAND   437   442  6      
STRAND   444   452  9      
HELIX   453   455  3      
HELIX   456   467  12      
Sequence information
Length: 473 AA [This is the length of the unprocessed precursor] Molecular weight: 51392 Da [This is the MW of the unprocessed precursor] CRC64: 811C6E0F4B66BC5F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTTVMKFGGT SVGSGERIRH VAKIVTKRKK EDDDVVVVVS AMSEVTNALV EISQQALDVR 

        70         80         90        100        110        120 
DIAKVGDFIK FIREKHYKAI EEAIKSEEIK EEVKKIIDSR IEELEKVLIG VAYLGELTPK 

       130        140        150        160        170        180 
SRDYILSFGE RLSSPILSGA IRDLGEKSIA LEGGEAGIIT DNNFGSARVK RLEVKERLLP 

       190        200        210        220        230        240 
LLKEGIIPVV TGFIGTTEEG YITTLGRGGS DYSAALIGYG LDADIIEIWT DVSGVYTTDP 

       250        260        270        280        290        300 
RLVPTARRIP KLSYIEAMEL AYFGAKVLHP RTIEPAMEKG IPILVKNTFE PESEGTLITN 

       310        320        330        340        350        360 
DMEMSDSIVK AISTIKNVAL INIFGAGMVG VSGTAARIFK ALGEEEVNVI LISQGSSETN 

       370        380        390        400        410        420 
ISLVVSEEDV DKALKALKRE FGDFGKKSFL NNNLIRDVSV DKDVCVISVV GAGMRGAKGI 

       430        440        450        460        470 
AGKIFTAVSE SGANIKMIAQ GSSEVNISFV IDEKDLLNCV RKLHEKFIEK TNS
Q57991 in FASTA format

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