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UniProtKB/Swiss-Prot entry Q4WVG8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNLI4_ASPFU
Primary accession number Q4WVG8
Secondary accession numbers None
Integrated into Swiss-Prot on February 20, 2007
Sequence was last modified on July 5, 2005 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 24)
Name and origin of the protein
Protein name DNA ligase 4
Synonyms EC 6.5.1.1
DNA ligase IV
Polydeoxyribonucleotide synthase [ATP] 4
Gene name
Name: lig4
ORFNames: AFUA_5G12050
From
Aspergillus fumigatus (Sartorya fumigata) [TaxID: 5085] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae; mitosporic Trichocomaceae; Aspergillus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Af293 / CBS 101355 / FGSC A1100;
DOI=10.1038/nature04332; PubMed=16372009 [NCBI, ExPASy, EBI, Israel, Japan]
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.;
"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.";
Nature 438:1151-1156(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAHF01000003; EAL91408.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_753446.1; -.
3D structure databases
ModBase Q4WVG8.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0003910; Molecular function: DNA ligase (ATP) activity (inferred from electronic annotation from InterPro).
GO:0006310; Biological process: DNA recombination (inferred from electronic annotation from InterPro).
GO:0006281; Biological process: DNA repair (inferred from electronic annotation from InterPro).
GO:0006260; Biological process: DNA replication (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001357; BRCT.
IPR000977; DNA_ligase.
IPR012309; DNA_ligase_A_C.
IPR012310; DNA_ligase_A_M.
IPR016059; DNA_ligase_CS.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.
Gene3D G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
Pfam PF00533; BRCT; 2.
PF04679; DNA_ligase_A_C; 1.
PF01068; DNA_ligase_A_M; 1.
Pfam graphical view of domain structure.
SMART SM00292; BRCT; 1.
SMART graphical view of domain structure.
TIGRFAMs TIGR00574; dnl1; 1.
PROSITE PS50172; BRCT; 1.
PS00697; DNA_LIGASE_A1; 1.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q4WVG8.
Genome annotation databases
GeneID 3511447; -.
KEGG afm:AFUA_5G12050; -.
Phylogenomic databases
HOGENOM Q4WVG8; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding; Nucleus; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   979  979     DNA ligase 4. PRO_0000278375
DOMAIN   721   814  94     BRCT 1. 
DOMAIN   867   965  99     BRCT 2. 
ACT_SITE   322   322        N6-AMP-lysine intermediate (By similarity). 
Sequence information
Length: 979 AA [This is the length of the unprocessed precursor] Molecular weight: 111878 Da [This is the MW of the unprocessed precursor] CRC64: 2E5C1E83EB5F302A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDSDEIMPDE EHPNVPVGDE ESDIDEKYPN RPRNHSPTLP FHELFQTLFN PLGEIKKKPA 

        70         80         90        100        110        120 
GAVAARRKVG PHGQSAANLN PLERRRDVIE RFISRWRKEV GDDIYPAFRL ILPDKDRDRA 

       130        140        150        160        170        180 
MYGIKEKAIG KMLVKIMKID KNSEDGFNLL NWKLPGQAAT SRMTGDFAGR CFDVISKRPM 

       190        200        210        220        230        240 
RTDVGDMLIE EVNEKLDKLS AASKEEQQLP ILAEFYRRMN PEELMWLIRI ILRQMKVGAT 

       250        260        270        280        290        300 
ERTFFDVWHP DAENLYSISS SLRRVCWELH DPNIRLDAED RGISLMQCFQ PQLAQFQMDS 

       310        320        330        340        350        360 
LDRMVARMRP TEEDPVFWIE EKLDGERMQL HMASDDSVPG GRRFRFWSRK AKEYTYLYGN 

       370        380        390        400        410        420 
GIYDENGSLT RYLKDAFADG VQSLILDGEM ITWDPEQDAP APFGTLKTAA LSEQRNPFST 

       430        440        450        460        470        480 
TGARPLLRVF DILYLNGRDL TGYTLRDRRK ALQKAVRPVH RRFEIHPYEE ATTKDQVEAA 

       490        500        510        520        530        540 
LRKVVAEASE GLVLKNPRSP YRLNERHDDW MKVKPEYMTE FGESLDLIVI GGYYGSGRRG 

       550        560        570        580        590        600 
GNLSSFLCGL RVDDGHASQG ASASKCYSFC KVGGGFNAAD YANIRHHTDG KWMEWNPKKP 

       610        620        630        640        650        660 
PTAYIELAGR DAQYERPDMW IKPEDSVVIC VKAASVSASD QFRLGLTLRF PRFKRLRMDK 

       670        680        690        700        710        720 
DWKSALSVQE FLDLKSNVEQ EHREKELNVD NSRRKRVKRT AKKPLTVAGY DMDEDVKYAG 

       730        740        750        760        770        780 
PSGHIFDGLN FYILTDSSAP IKKTKPELEQ LVKANGGMFF QTNNAAPHTI CVADRRTVKA 

       790        800        810        820        830        840 
ASLQKRGDVD IIRPSWIIDC VKQNEIDAGL PDFLLPFEPR HMFFATPGKH DEVASNVDQF 

       850        860        870        880        890        900 
GDSYARDTTS EELSDCPESI TKLIERLQES VNSGHEMPCG LLFKSLTILF PHRNDDVSES 

       910        920        930        940        950        960 
EAKTSSHPSI THVVIDPESS SKEISSLRGK WSRKPGRKVP HIVTVDWVEE SWKSRTLLDE 

       970 
ERFQPKRCIS GIAKPYWPG 

Q4WVG8 in FASTA format

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View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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