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UniProtKB/Swiss-Prot entry Q4WPV8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HPPD2_ASPFU
Primary accession number Q4WPV8
Secondary accession numbers None
Integrated into Swiss-Prot on December 6, 2005
Sequence was last modified on July 5, 2005 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 27)
Name and origin of the protein
Protein name Probable 4-hydroxyphenylpyruvate dioxygenase 2
Synonyms HPPDase 2
4HPPD 2
HPD 2
EC 1.13.11.27
Gene name
ORFNames: AFUA_4G10620
From
Aspergillus fumigatus (Sartorya fumigata) [TaxID: 5085] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae; mitosporic Trichocomaceae; Aspergillus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Af293 / CBS 101355 / FGSC A1100;
DOI=10.1038/nature04332; PubMed=16372009 [NCBI, ExPASy, EBI, Israel, Japan]
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.;
"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.";
Nature 438:1151-1156(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAHF01000005; EAL89726.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_751764.1; -.
3D structure databases
ModBase Q4WPV8.
Ontologies
GO
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006559; Biological process: L-phenylalanine catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006572; Biological process: tyrosine catabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR005956; 4OHPhenylPyrv_dOase.
IPR004360; Glyas_bleo-R_dOase.
Graphical view of domain structure.
PANTHER PTHR11959; HPP_dOase; 1.
Pfam PF00903; Glyoxalase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF009283; HPP_dOase; 1.
TIGRFAMs TIGR01263; 4HPPD; 1.
BLOCKS Q4WPV8.
ProtoNet Q4WPV8.
Genome annotation databases
GeneID 3509500; -.
KEGG afm:AFUA_4G10620; -.
Phylogenomic databases
HOGENOM Q4WPV8; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   406  406     Probable 4-hydroxyphenylpyruvate dioxygenase 2. PRO_0000088402
METAL   208   208        Iron (By similarity). 
METAL   291   291        Iron (By similarity). 
METAL   374   374        Iron (By similarity). 
Sequence information
Length: 406 AA [This is the length of the unprocessed precursor] Molecular weight: 45776 Da [This is the MW of the unprocessed precursor] CRC64: BF038D6775106A55 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTVSKKVEEN IFASKLGPEY VGFDHITWYV GNAKQAASYY VTRMGFKQIA YRGPETGSRS 

        70         80         90        100        110        120 
VVSHVISNGQ AIFVLTSPIR SMAGTGAYDD DPDVTKADRR LLEEIHNHLI KHGDGVKDVA 

       130        140        150        160        170        180 
FRIEGDIEAV WKRAVDHGAA PVAAPTTLKD DRHGSITLAT IGTYEDTVHS LINRHDYSGP 

       190        200        210        220        230        240 
FLPGYEVVTD DDPINRLLPS IDFIEIDHCV GNQPWNGVDP IVKYYEDCLN FHRYWTVDDL 

       250        260        270        280        290        300 
NMCGEYSAMR SIVVASPNEV IKMPMNEPAQ GKKKSQIEEF VNYYNGAGVQ HIAFRTHDIV 

       310        320        330        340        350        360 
TAVTRLRERG VSFLEVPSAY YSDLRQRLSH TGLTLEEDIA VLEKLHILVD FDEKGYLLQI 

       370        380        390        400 
FSKHVLDRPT VFIEVIQRNN FDGFGAGNFK SLFEAFEREQ ARRGNL 

Q4WPV8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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