NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P.;
"Complete sequence of Dechloromonas aromatica RCB.";
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000089; AAZ46688.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_285158.1; -.

3D structure databases

ModBase

Q47EP3.

Enzyme and pathway databases

BioCyc

DARO159087:DARO_1942-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0045020;	Biological process: error-prone DNA repair (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01902; -; 1.
PBIL [Tree]

InterPro

IPR011708; DNA_pol3_alpha.
IPR004365; NA_bd_OB_tRNA-helicase.
IPR004013; PHP_C.
IPR003141; PHP_N.
IPR004805; PolC_alpha.
Graphical view of domain structure.

Pfam

PF07733; DNA_pol3_alpha; 1.
PF02811; PHP; 1.
PF01336; tRNA_anti; 1.
Pfam graphical view of domain structure.

SMART

SM00481; POLIIIAc; 1.
SMART graphical view of domain structure.

TIGR00594; polc; 1.

Genome annotation databases

GeneID

3567871; -.

GenomeReviews

CP000089_GR; Daro_1942.

KEGG

dar:Daro_1942; -.

NMPDR

fig|159087.4.peg.1954; -.

Phylogenomic databases

HOGENOM

Q47EP3; -.

Genome annotation databases

CMR

Q47EP3; Daro_1942.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1027`	`1027`		`Error-prone DNA polymerase.`	`PRO_1000070590`

Sequence information

Length: 1027 AA [This is the length of the unprocessed precursor]

Molecular weight: 113395 Da [This is the MW of the unprocessed precursor]

CRC64: C83D577695B12DCF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSLPEYAELH CLSNFSFLRG ASHPEELAAR ALAQGYAALA LTDECSLAGV VRAHLAAKKH 

        70         80         90        100        110        120 
GLKFIVGSEM MTVDGLKLVF LACNRHGYGN LSALITLARR RAEKGGYTLH RNDLESISPS 

       130        140        150        160        170        180 
GALPDCLVLW VPGNNPSSAD GEWLVSRFPG RSWIAVELHA GPEDAERLAG LQSLGEVCGL 

       190        200        210        220        230        240 
PLVATGDVHM HIKARRPVQD VLTALRLKST VFEAGYALFP NGERHLRSRL RLSRLYPPEL 

       250        260        270        280        290        300 
LAETLNIAAR CEFLLDELRY EYPEEIIPSG ETPASWLRSE TERGLQRRYP AGVPGSVRER 

       310        320        330        340        350        360 
IEHELGLIAE MAYEAYFLTV YDIVCYARSQ DILCQGRGSA ANSAVCYALG VTEVDPARSA 

       370        380        390        400        410        420 
LLFERFVSKE RGEPPDIDVD FEHERREDVI QYIYTKYGRE RAALAAALIT YRTKGALRDA 

       430        440        450        460        470        480 
GRALGFGIAQ INALTASLAW WDKREQLPER FAELGLDPHA PRVEKWLAIA EALRGFPRHL 

       490        500        510        520        530        540 
TQHVGGFVIS RGPLSRLVPV ENAAMSARSV IQWDKDDLDA MGLMKVDILA LGMLSAIRRM 

       550        560        570        580        590        600 
LQIVGETTGR PMKMQDIPAE DPATYEMLCH ADSMGVFQVE SRAQMAMLPR LRPQNFYDLV 

       610        620        630        640        650        660 
VEVALVRPGP IQGDMVHPYL KRRQGRERIE EISPAVDAVL ERTYGVPIFQ EQVMQLAVVA 

       670        680        690        700        710        720 
ANFTPGEADQ LRRAMAAWKR KGGLEPFEQK LLAGMAANDL PESFARRIIA QIQGFGEYGF 

       730        740        750        760        770        780 
PESHAASFAL LVYASAWLKR HHPAAFLCGL LNSQPMGFYS PSMLIQDARR HGVRVLPPDV 

       790        800        810        820        830        840 
MTSDWDSRLD ERGAVRLGLR EISGFSVAAA KRITAVCREN QPFLNVADLA ARAGLQRRDL 

       850        860        870        880        890        900 
DLLAAGDALQ GLAGHRRQAA WAATVAVVQG DLFDGTPVVE AEIELPAPSD GENLVADYRS 

       910        920        930        940        950        960 
LGLTLRSHPL SLLRQYLAER RFVTAADLKM AGHHTLIRSV GIVVGRQRPG TATGIVFVTL 

       970        980        990       1000       1010       1020 
EDETGLSNVV VHPQLVEKQR RELLGSTLLG VYGQLQVEGE VVHLVAKRLV DLSAWLGRLE 


TVSRDFH

Q47EP3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools