[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=cv. Nipponbare; DOI=10.1186/1741-7007-3-20; PubMed=16188032 [NCBI, ExPASy, EBI, Israel, Japan] The rice chromosomes 11 and 12 sequencing consortia; "The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."; BMC Biol. 3:20-20(2005).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=cv. Nipponbare; DOI=10.1038/nature03895; PubMed=16100779 [NCBI, ExPASy, EBI, Israel, Japan] International rice genome sequencing project (IRGSP); "The map-based sequence of the rice genome."; Nature 436:793-800(2005).
[3]	GENOME REANNOTATION. STRAIN=cv. Nipponbare; DOI=10.1101/gr.5509507; PubMed=17210932 [NCBI, ExPASy, EBI, Israel, Japan] The rice annotation project (RAP); "Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana."; Genome Res. 17:175-183(2007).

Comments

FUNCTION: Lignin degradation and detoxification of lignin-derived products (By similarity).
CATALYTIC ACTIVITY: 4 benzenediol + O₂ = 4 benzosemiquinone + 2 H₂O.
COFACTOR: Binds 4 copper ions per monomer (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, apoplast (Potential).
SIMILARITY: Belongs to the multicopper oxidase family.
SIMILARITY: Contains 3 plastocyanin-like domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

DP000010; ABA95555.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AP008217; BAF28876.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001068513.1; -.

UniGene

Os.72229

3D structure databases

ModBase

Q2QZ80.

Organism-specific databases

Gramene

Q2QZ80; -.

Ontologies

GO:0048046;	Cellular component: apoplast (inferred from electronic annotation from UniProtKB-KW).
GO:0008471;	Molecular function: laccase activity (inferred from electronic annotation from EC).
GO:0046274;	Biological process: lignin catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001117; Cu-oxidase.
IPR011706; Cu-oxidase_2.
IPR011707; Cu-oxidase_3.
IPR002355; Cu_oxidase_Cu_BS.
IPR008972; Cupredoxin.
IPR017761; Laccase.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.420; Cupredoxin; 3.

Pfam

PF00394; Cu-oxidase; 1.
PF07731; Cu-oxidase_2; 1.
PF07732; Cu-oxidase_3; 1.
Pfam graphical view of domain structure.

PROSITE

PS00079; MULTICOPPER_OXIDASE1; 1.
PS00080; MULTICOPPER_OXIDASE2; 1.

Genome annotation databases

GeneID

4351179; -.

KEGG

osa:4351179; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Apoplast; Copper; Glycoprotein; Lignin degradation; Metal-binding; Oxidoreductase; Repeat; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 29`	`29`	`Potential.`
`CHAIN`	`30 583`	`554`	`Laccase-21.`	`PRO_0000291908`
`DOMAIN`	`39 155`	`117`	`Plastocyanin-like 1.`
`DOMAIN`	`165 323`	`159`	`Plastocyanin-like 2.`
`DOMAIN`	`436 567`	`132`	`Plastocyanin-like 3.`
`METAL`	`89 89`		`Copper 1 (By similarity).`
`METAL`	`91 91`		`Copper 2 (By similarity).`
`METAL`	`134 134`		`Copper 2 (By similarity).`
`METAL`	`136 136`		`Copper 3 (By similarity).`
`METAL`	`484 484`		`Copper 4 (By similarity).`
`METAL`	`487 487`		`Copper 1 (By similarity).`
`METAL`	`489 489`		`Copper 3 (By similarity).`
`METAL`	`546 546`		`Copper 3 (By similarity).`
`METAL`	`547 547`		`Copper 4 (By similarity).`
`METAL`	`548 548`		`Copper 2 (By similarity).`
`METAL`	`552 552`		`Copper 4 (By similarity).`
`METAL`	`557 557`		`Copper 4 (By similarity).`
`CARBOHYD`	`85 85`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`282 282`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`311 311`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`384 384`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`387 387`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`399 399`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`409 409`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`446 446`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 583 AA [This is the length of the unprocessed precursor]

Molecular weight: 64864 Da [This is the MW of the unprocessed precursor]

CRC64: 14383B2F326D0A63 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGIAKIPAVL WLLACAVLTF AVAISPAHGG RTRRHYDFFI TETNYRRLCH EKSVLTVNGQ 

        70         80         90        100        110        120 
FPGPTIYARK GDLVIVNVYN HGNKNITIHW HGVDQPRNPW SDGPEFITQC PIRPDGKFTY 

       130        140        150        160        170        180 
QVIMSEEEGT LWWHAHSDFD RATVLGAIVV HPKHGDTFPF KRPDKEIPII LGEWWKNDVN 

       190        200        210        220        230        240 
HLLEEMKRIG EDVKPSDANT INGQPGDMFP CSRDDTFKVA VEHGNTYLLQ VINAGLTNDM 

       250        260        270        280        290        300 
FFAVSGHRLT VVGIDARYTK PLTVEYIMIA PGQTMDLLLE ANRSLGSKSN SRYYMAARTF 

       310        320        330        340        350        360 
ITLPVPIPFN NSTATAVVEY YTGDSGAGPP DFPAVLPSLD DVDAAMAFLR QLRSLGSKDH 

       370        380        390        400        410        420 
PVHVPTHVDE HMLIDLAINF LPCNATNATD TACKGPKGNT TRFAASLNNV SFVSPAIDVL 

       430        440        450        460        470        480 
HAYYYGSGRG VYEDDFPNNP APVFVNLTGD NDRPGVTKHG AKVKVLEYGT VVEVVFQDTS 

       490        500        510        520        530        540 
FESHPMHLHG FAFYVVGLGS GKFDDRRDPA TYNLLDPPYQ STVSVPKAGW AAIRFRADNP 

       550        560        570        580 
GVWFMHCHFD RHMVWGMNTV FIVKDGKTPQ AQMLPRPPNM PKC

Q2QZ80 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools