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UniProtKB/Swiss-Prot entry Q29HB2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MMSA_DROPS
Primary accession number Q29HB2
Secondary accession numbers None
Integrated into Swiss-Prot on December 4, 2007
Sequence was last modified on April 4, 2006 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 17)
Name and origin of the protein
Protein name Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [Precursor]
Synonyms MMSDH
Malonate-semialdehyde dehydrogenase [acylating]
EC 1.2.1.27
EC 1.2.1.18
Gene name
ORFNames: GA14712
From
Drosophila pseudoobscura pseudoobscura (Fruit fly) [TaxID: 46245] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MV2-25;
DOI=10.1101/gr.3059305; PubMed=15632085 [NCBI, ExPASy, EBI, Israel, Japan]
Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.;
"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution.";
Genome Res. 15:1-18(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CH379064; EAL31846.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_001354791.1; -.
3D structure databases
ModBase Q29HB2.
Organism-specific databases
FlyBase FBgn0074739; Dpse\GA14712.
Ontologies
GO
GO:0000062; Molecular function: acyl-CoA binding (inferred from sequence or structural similarity from UniProtKB).
GO:0018478; Molecular function: malonate-semialdehyde dehydrogenase (acetylating) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0004491; Molecular function: methylmalonate-semialdehyde dehydrogenase (acylating) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0019859; Biological process: thymine metabolic process (inferred from sequence or structural similarity from UniProtKB).
GO:0006573; Biological process: valine metabolic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR010061; MeMal-semiAld_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF27; MMSDH; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01722; MMSDH; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; FALSE_NEG.
BLOCKS Q29HB2.
ProtoNet Q29HB2.
Genome annotation databases
GeneID 4815188; -.
KEGG dpo:Dpse_GA14712; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   520        Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial. PRO_0000312824
NP_BIND   195   199  5     NAD (Potential). 
NP_BIND   247   252  6     NAD (Potential). 
ACT_SITE   303   303        Nucleophile (By similarity). 
BINDING   403   403        NAD (Potential). 
Sequence information
Length: 520 AA [This is the length of the unprocessed precursor] Molecular weight: 56064 Da [This is the MW of the unprocessed precursor] CRC64: E8336961D816B35D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAFLRAIGAE ARYLTQRAYS SAAPTTKLFI DGKFVESKTK EWIDVHDPAT NKVVTRVPKA 

        70         80         90        100        110        120 
TQDEMQTALE SNKKAFRSWS NQSILTRQAV MFKLQALIKE NMGELAKNIT KEQGKTLADA 

       130        140        150        160        170        180 
EGDVLRGLQV VEHCCSIPSL QMGETVANVA RDMDTYSLVM PLGVTAGIAP FNFPAMIPLW 

       190        200        210        220        230        240 
MFPVAITTGN TMLLKPSERV PGATMLLMEL LNEAGCPPGV VNVIHGQHDA VNFICDAPAI 

       250        260        270        280        290        300 
KAVSFVGSDQ AGKYIYERAG KNGKRVQSNM GAKNHGVILS DANKENTLNQ LAGAAFGAAG 

       310        320        330        340        350        360 
QRCMALSTAV FVGDAQGWIP DLVERAQKLK VNAGHVPGTD VGPVISAASR QRINDLIESG 

       370        380        390        400        410        420 
VKEGAKLILD GRKISVPGFE DGYFVGPTIL SDVTPSMKCY TEEIFGPVLV ILKADNLDDA 

       430        440        450        460        470        480 
IDIVNANPYG NGTAVFTTNG AAARKFVNEI DAGQVGVNVP IPVPLPMFSF TGTRGSFRGD 

       490        500        510        520 
HHFYGKQGIK FYTQTKTVTQ LWRETDVNHT QAAVAMPTMK
Q29HB2 in FASTA format

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