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UniProtKB/Swiss-Prot entry Q28505

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FMO2_MACMU
Primary accession number Q28505
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 60)
Name and origin of the protein
Protein name Dimethylaniline monooxygenase [N-oxide-forming] 2
Synonyms EC 1.14.13.8
Pulmonary flavin-containing monooxygenase 2
FMO 2
FMO 1B1
Dimethylaniline oxidase 2
Gene name
Name: FMO2
From
Macaca mulatta (Rhesus macaque) [TaxID: 9544] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/S0167-4781(97)00004-3; PubMed=9061021 [NCBI, ExPASy, EBI, Israel, Japan]
Yueh M.-F., Krueger S.K., Williams D.E.;
"Pulmonary flavin-containing monooxygenase (FMO) in rhesus macaque: expression of FMO2 protein, mRNA and analysis of the cDNA.";
Biochim. Biophys. Acta 1350:267-271(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U59453; AAB02939.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001036242.1; -.
UniGene Mmu.3381
3D structure databases
ModBase Q28505.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR012143; dManiline_mOase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR000960; Flavin_mOase.
IPR002254; Flavin_mOase_2.
Graphical view of domain structure.
Pfam PF00743; FMO-like; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000332; FMO; 1.
PRINTS PR00368; FADPNR.
PR00370; FMOXYGENASE.
PR01122; FMOXYGENASE2.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
BLOCKS Q28505.
ProtoNet Q28505.
Genome annotation databases
Ensembl ENSMMUG00000019727; Macaca mulatta. [Contig view]
GeneID 703639; -.
KEGG mcc:703639; -.
Phylogenomic databases
HOVERGEN Q28505; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Endoplasmic reticulum; FAD; Flavoprotein; Magnesium; Membrane; Microsome; Monooxygenase; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   535  534     Dimethylaniline monooxygenase [N-oxide-forming] 2. PRO_0000147647
NP_BIND   9    14  6     FAD (Potential). 
NP_BIND   191   196  6     NADP (Potential). 
MOD_RES   2     2        N-acetylalanine (By similarity). 
Sequence information
Length: 535 AA [This is the length of the unprocessed precursor] Molecular weight: 60961 Da [This is the MW of the unprocessed precursor] CRC64: 85621203B07CCFAE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAKKVAVIGA GVSGLISLKC CVDEGLEPTC FERTEDIGGV WRFKEKVEDG RASIYQSVVT 

        70         80         90        100        110        120 
NTSKEMSCFS DFPMPEDFPN FLHNSKLLEY FRIFAKKFDL LKYIQFQTTV LSVRKCPDFS 

       130        140        150        160        170        180 
SSGQWKVVTQ SNGKEQSAVF DAVMVCTGHH FLPHIPLKSF PGIERFKGQY FHSRQYKHPD 

       190        200        210        220        230        240 
GFEGKRILVI GMGNSGSDIA VELSKSAAQV FISTRHGTWV MSRVSEDGYP WDSVFHTRFR 

       250        260        270        280        290        300 
SMLRNVLPRT VVKWMIEQQM NQWFNHENYG LEPQNKYIMK EPVLNDDVPS RLLCGAIKVK 

       310        320        330        340        350        360 
STVKELTETS AIFEDGTVEE NIDVIIFATG YSFSFPFLED SLVKVENNMV SLYKYIFPAH 

       370        380        390        400        410        420 
LEKSTFACIG LIQPLGSIFP TAELQARWVT RVFKGLCHLP SERTMMMDII KRNEKRIDLF 

       430        440        450        460        470        480 
GESQSQTLQT NYVDYLDELA LEIGAKPDFC SLLFKDPKLA VRLFFGPCNS YQYRLAGPGQ 

       490        500        510        520        530 
WEGARSAIFT QKQRILKPLK TRVLKDSSNF PVSFLLKILG LVAVVVAFFC QLQWS
Q28505 in FASTA format

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