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UniProtKB/Swiss-Prot entry Q27464

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G6PD_CAEEL
Primary accession number Q27464
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 54)
Name and origin of the protein
Protein name Glucose-6-phosphate 1-dehydrogenase
Synonyms G6PD
EC 1.1.1.49
Gene name
ORFNames: B0035.5
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z73102; CAA97412.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T18657; T18657.
RefSeq NP_502129.1; -.
UniGene Cel.8269
3D structure databases
HSSP P11413; 1QKI. [HSSP ENTRY / PDB]
ModBase Q27464.
Organism-specific databases
WormBase WBGene00007108; B0035.5.
WormPep B0035.5; CE05163. [WormPep / WorfDB]
Gene expression databases
ArrayExpress Q27464; -.
Ontologies
GO
GO:0009792; Biological process: embryonic development ending in birth or egg hatching (inferred from mutant phenotype from WormBase).
GO:0040010; Biological process: positive regulation of growth rate (inferred from mutant phenotype from WormBase).
QuickGo view.
Family and domain databases
InterPro IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23429; G6PDH; 1.
Pfam PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000110; G6PD; 1.
PRINTS PR00079; G6PDHDRGNASE.
ProDom PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00871; zwf; 1.
PROSITE PS00069; G6P_DEHYDROGENASE; 1.
BLOCKS Q27464.
ProtoNet Q27464.
Genome annotation databases
Ensembl B0035.5; Caenorhabditis elegans. [Contig view]
GeneID 178046; -.
KEGG cel:B0035.5; -.
Other
NextBio 899498; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   522  522     Glucose-6-phosphate 1-dehydrogenase. PRO_0000068089
ACT_SITE   269   269        Proton acceptor (By similarity). 
BINDING   42    42        NADP (By similarity). 
BINDING   74    74        NADP (By similarity). 
BINDING   207   207        Substrate (By similarity). 
BINDING   211   211        Substrate (By similarity). 
BINDING   372   372        Substrate (By similarity). 
Sequence information
Length: 522 AA [This is the length of the unprocessed precursor] Molecular weight: 60215 Da [This is the MW of the unprocessed precursor] CRC64: 7329CC6508B8E378 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MACKRHSVSD PISKDLVECL RESMQRDLKF ETPYVFVIFG ASGDLAKKKI YPTLWWLFRD 

        70         80         90        100        110        120 
NLLPVNIKFI GYARSDLTVF KLRESFEKNC KVRENEKCAF DDFIKKCSYV QGQYDTSEGF 

       130        140        150        160        170        180 
QRLQSSIDDF QKESNNQAVN RLYYLALPPS VFNVVSTELK KNCMDHGDSW TRVIIEKPFG 

       190        200        210        220        230        240 
HDLKSSCELS THLAKLFKED QIYRIDHYLG KEMVQNLMVM RFGNRILAPS WNRDHIASVM 

       250        260        270        280        290        300 
ISFKEDFGTG GRAGYFDTAG IIRDVMQNHL MQILTLVAME KPASLNAEDI RDEKVKVLKA 

       310        320        330        340        350        360 
AKVVELKDVV VGQYIASPEF DHPEASQGYK DDKSVPADST TPTYALAVVH INNERWEGVP 

       370        380        390        400        410        420 
FFLRCGKALN EKKAEVRIQF KEVSGDIYPS GELKRSELVM RVQPNEAVYM KLMTKKPGMG 

       430        440        450        460        470        480 
FGVEETELDL TYNNRFKEVR LPDAYERLFL EVFMGSQINF VRTDELEYAW RILTPVLEEL 

       490        500        510        520 
KKKKVQPVQY KFGSRGPTEG DELMKKYGFI FTGTYKWVAP KL
Q27464 in FASTA format

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