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UniProtKB/Swiss-Prot entry Q1QPR8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HGD_NITHX
Primary accession number Q1QPR8
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on May 16, 2006 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 19)
Name and origin of the protein
Protein name Homogentisate 1,2-dioxygenase
Synonyms EC 1.13.11.5
Homogentisicase
Homogentisate oxygenase
Homogentisic acid oxidase
Gene name
Name: hmgA
OrderedLocusNames: Nham_0921
From
Nitrobacter hamburgensis (strain X14 / DSM 10229) [TaxID: 323097] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Bradyrhizobiaceae; Nitrobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Ward B., Arp D., Klotz M., Stein L., O'Mullan G., Starkenburg S., Sayavedra L., Poret-Peterson A.T., Gentry M.E., Bruce D., Richardson P.;
"Complete sequence of chromosome of Nitrobacter hamburgensis X14.";
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000319; ABE61779.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_576239.1; -.
3D structure databases
ModBase Q1QPR8.
Enzyme and pathway databases
BioCyc NHAM323097:NHAM_0921-MON; -.
Ontologies
GO
GO:0004411; Molecular function: homogentisate 1,2-dioxygenase activity (inferred from electronic annotation from HAMAP).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from HAMAP).
GO:0006559; Biological process: L-phenylalanine catabolic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006572; Biological process: tyrosine catabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00334; -; 1.
PBIL [Tree]
InterPro IPR005708; Homogentis_dOase.
Graphical view of domain structure.
PANTHER PTHR11056; Homogentis_dOase; 1.
Pfam PF04209; HgmA; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01015; hmgA; 1.
BLOCKS Q1QPR8.
ProtoNet Q1QPR8.
Genome annotation databases
GeneID 4031915; -.
GenomeReviews CP000319_GR; Nham_0921.
KEGG nha:Nham_0921; -.
NMPDR fig|323097.3.peg.895; -.
Phylogenomic databases
HOGENOM Q1QPR8; -.
Genome annotation databases
CMR Q1QPR8; Nham_0921.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   448  448     Homogentisate 1,2-dioxygenase. PRO_1000019531
METAL   346   346        Iron (By similarity). 
METAL   352   352        Iron (By similarity). 
METAL   382   382        Iron (By similarity). 
Sequence information
Length: 448 AA [This is the length of the unprocessed precursor] Molecular weight: 49674 Da [This is the MW of the unprocessed precursor] CRC64: 1E4007C93C156DCA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNTSFDPVAA NSNSANVTPG YMSGFGNSFE TEALPGALPI GRNSPQRCAY GLYAEQLSGS 

        70         80         90        100        110        120 
PFTAPRGANE RSWLYRIRPS VRHSGHFVKI DAKLWRTAPC LEHDMPLAQL RWDPTPIPED 

       130        140        150        160        170        180 
ELTFVQSVRT MTTAGDAHTQ TGMAAHIYLI TRSMVDQHFY NADGEMLFVP QGGSLRFVTE 

       190        200        210        220        230        240 
FGVIDTEPGE IAVIPRGVKF RVEIPSGPAR GYLCENYGGA FTLPERGPIG ANCLANSRDF 

       250        260        270        280        290        300 
LTPVAAYEDD DKPTELFVKW GGALWSTALP HSPIDVVAWH GNYAPYKYDL RTFSPIGAIG 

       310        320        330        340        350        360 
FDHPDPSIFT VLTSPSEIAG TANIDFVIFP ERWVVAENTF RPPWYHMNVM SEFMGLIYGV 

       370        380        390        400        410        420 
YDAKPQGFVP GGISLHNCML PHGPDREAFD HASNTELKPV KLTGTLAFMF ETRFPQRVTE 

       430        440 
YAATSDALQD DYADCWQGLE RRFDPTRP
Q1QPR8 in FASTA format

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