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UniProtKB/Swiss-Prot entry P59997


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name JHD1A_MOUSE
Primary accession number P59997
Secondary accession numbers Q3U1M5 Q3UR56 Q3V3Q1 Q69ZT4
Integrated into Swiss-Prot on November 7, 2003
Sequence was last modified on March 7, 2006 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 53)
Name and origin of the protein
Protein name JmjC domain-containing histone demethylation protein 1A
Synonyms EC 1.14.11.27
[Histone-H3]-lysine-36 demethylase 1A
F-box and leucine-rich repeat protein 11
F-box/LRR-repeat protein 11
Gene name
Name: Fbxl11
Synonyms: Jhdm1a, Kiaa1004
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 646-1161.
STRAIN=C57BL/6J;
TISSUE=Skin;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6;
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 453-1161.
TISSUE=Thymus;
DOI=10.1093/dnares/11.3.205; PubMed=15368895 [NCBI, ExPASy, EBI, Israel, Japan]
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.";
DNA Res. 11:205-218(2004).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-632, AND MASS SPECTROMETRY.
DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.";
Science 316:1160-1166(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK037157; BAE20506.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK141779; BAE24832.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK155866; BAE33470.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC057051; AAH57051.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC076576; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
AK173084; BAD32362.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001001984.2; -.
UniGene Mm.31941
3D structure databases
SMR P59997; 36-364, 450-517.
ModBase P59997.
PTM databases
PhosphoSite P59997; -.
Organism-specific databases
MGI MGI:1354736; Fbxl11.
Gene expression databases
ArrayExpress P59997; -.
CleanEx MM_FBXL11; -.
GermOnline ENSMUSG00000054611; Mus musculus.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
GO:0003677; Molecular function: DNA binding (inferred from electronic annotation from InterPro).
GO:0051864; Molecular function: histone demethylase activity (H3-K36 specific) (inferred from electronic annotation from EC).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0016702; Molecular function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (inferred from electronic annotation from UniProtKB-KW).
GO:0005515; Molecular function: protein binding (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0016568; Biological process: chromatin modification (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0006511; Biological process: ubiquitin-dependent protein catabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001810; F-box.
IPR001611; LRR.
IPR013129; TF_JmjC.
IPR003347; TF_JmjC_AAH.
IPR002857; Znf_CXXC.
IPR001965; Znf_PHD.
Graphical view of domain structure.
Pfam PF00646; F-box; 1.
PF02373; JmjC; 1.
PF00560; LRR_1; 1.
PF02008; zf-CXXC; 1.
Pfam graphical view of domain structure.
SMART SM00256; FBOX; 1.
SM00558; JmjC; 1.
SM00249; PHD; 1.
SMART graphical view of domain structure.
PROSITE PS50181; FBOX; FALSE_NEG.
PS51184; JMJC; 1.
PS51058; ZF_CXXC; 1.
PS01359; ZF_PHD_1; 1.
PS50016; ZF_PHD_2; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P59997.
Genome annotation databases
Ensembl ENSMUSG00000054611; Mus musculus. [Contig view]
GeneID 225876; -.
KEGG mmu:225876; -.
Phylogenomic databases
HOGENOM P59997; -.
HOVERGEN P59997; -.
Other
NextBio 377841; -.
SOURCE Fbxl11; Mus musculus.
ROUGE KIAA1004.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Chromatin regulator; Dioxygenase; Iron; Leucine-rich repeat; Metal-binding; Nucleus; Oxidoreductase; Phosphoprotein; Repeat; Transcription; Transcription regulation; Ubl conjugation pathway; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1161  1161     JmjC domain-containing histone demethylation protein 1A. PRO_0000119856
DOMAIN   148    316  169     JmjC. 
DOMAIN   888    935  48     F-box. 
REPEAT   999   1024  26     LRR 1. 
REPEAT   1062   1090  29     LRR 2. 
REPEAT   1094   1117  24     LRR 3. 
ZN_FING   564    610  47     CXXC-type. 
ZN_FING   617    678  62     PHD-type. 
METAL   212    212        Iron; catalytic (By similarity). 
METAL   214    214        Iron; catalytic (By similarity). 
METAL   284    284        Iron; catalytic (By similarity). 
BINDING   209    209        Substrate (By similarity). 
BINDING   229    229        Substrate (By similarity). 
MOD_RES   28     28        Phosphoserine (By similarity). 
MOD_RES   390    390        Phosphoserine (By similarity). 
MOD_RES   394    394        Phosphoserine (By similarity). 
MOD_RES   534    534        Phosphothreonine (By similarity). 
MOD_RES   550    550        Phosphothreonine (By similarity). 
MOD_RES   558    558        Phosphoserine (By similarity). 
MOD_RES   632    632        Phosphothreonine. 
MOD_RES   692    692        Phosphoserine (By similarity). 
MOD_RES   713    713        Phosphothreonine (By similarity). 
MOD_RES   718    718        Phosphoserine (By similarity). 
MOD_RES   720    720        Phosphothreonine (By similarity). 
MOD_RES   721    721        Phosphoserine (By similarity). 
MOD_RES   731    731        Phosphoserine (By similarity). 
MOD_RES   739    739        Phosphoserine (By similarity). 
MOD_RES   740    740        Phosphoserine (By similarity). 
MOD_RES   868    868        Phosphoserine (By similarity). 
VAR_SEQ   321    338        PNKFRYPFYYEMCWYVLE -> SNVTIICVDVSPFKADVR (in isoform 3). VSP_017471
VAR_SEQ   339   1161        Missing (in isoform 3). VSP_017472
VAR_SEQ   494    494        I -> S (in isoform 2). VSP_017473
VAR_SEQ   495   1161        Missing (in isoform 2). VSP_017474
CONFLICT   159    159        W -> R (in Ref. 1; BAE20506 and 2; BC076576). 
CONFLICT   202    202        I -> M (in Ref. 1; BAE20506 and 2; BC076576). 
CONFLICT   913    913        M -> I (in Ref. 2; AAH57051). 
Sequence information
Length: 1161 AA [This is the length of the unprocessed precursor] Molecular weight: 132680 Da [This is the MW of the unprocessed precursor] CRC64: 210BD9F65BED0AE4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEPEEERIRY SQRLRGTMRR RYEDDGISDD EIEGKRTFDL EEKLQTNKYN ANFVTFMEGK 

        70         80         90        100        110        120 
DFNVEYIQRG GLRDPLIFKN SDGLGIKMPD PDFTVNDVKM CVGSRRMVDV MDVNTQKGIE 

       130        140        150        160        170        180 
MTMAQWTRYY ETPEEEREKL YNVISLEFSH TRLENMVQWP STVDFIDWVD NMWPRHLKES 

       190        200        210        220        230        240 
QTESTNAILE MQYPKVQKYC LISVRGCYTD FHVDFGGTSV WYHIHQGGKV FWLIPPTAHN 

       250        260        270        280        290        300 
LELYENWLLS GKQGDIFLGD RVSDCQRIEL KQGYTFVIPS GWIHAVYTPT DTLVFGGNFL 

       310        320        330        340        350        360 
HSFNIPMQLK IYSIEDRTRV PNKFRYPFYY EMCWYVLERY VYCITNRSHL TKDFQKESLS 

       370        380        390        400        410        420 
MDMELNELES GNGDEEGVDR EARRMNNKRS VLTSPVANGV NLDYDGLGKA CRSLPSLKKT 

       430        440        450        460        470        480 
LSGDSSSDST RGSHNGQVWD PQCSPKKDRQ VHLTHFELEG LRCLVDKLES LPLHKKCVPT 

       490        500        510        520        530        540 
GIEDEDALIA DVKILLEELA SSDPKLALTG VPIVQWPKRD KLKFPTRPKV RVPTIPITKP 

       550        560        570        580        590        600 
HTMKPAPRLT PVRPAAASPI VSGARRRRVR CRKCKACVQG ECGVCHYCRD MKKFGGPGRM 

       610        620        630        640        650        660 
KQSCVLRQCL APRLPHSVTC SLCGEVDQNE ETQDFEKKLM ECCICNEIVH PGCLQMDGEG 

       670        680        690        700        710        720 
LLNEELPNCW ECPKCYQEDS SDKAQKRKIE ESDEEAVQAK VLRPLRSCEE PLTPPPHSPT 

       730        740        750        760        770        780 
SMLQLIHDPV SPRGMVTRSS PGAGPSDHHS ASRDERFKRR QLLRLQATER TMVREKENNP 

       790        800        810        820        830        840 
SGKKELSEVE KAKIRGSYLT VTLQRPTKEL HGTSIVPKLQ AITASSANLR PNPRVLMQHC 

       850        860        870        880        890        900 
PARNPQHGDE EGLGGEEEEE EEEEEDDSAE EGGAARLNGR GSWAQDGDES WMQREVWMSV 

       910        920        930        940        950        960 
FRYLSRKELC ECMRVCKTWY KWCCDKRLWT KIDLSRCKAI VPQALSGIIK RQPVSLDLSW 

       970        980        990       1000       1010       1020 
TNISKKQLTW LVNRLPGLKD LLLAGCSWSA VSALSTSSCP LLRTLDLRWA VGIKDPQIRD 

      1030       1040       1050       1060       1070       1080 
LLTPPTDKPG QDNRSKLRNM TDFRLAGLDI TDATLRLIIR HMPLLSRLDL SHCSHLTDQS 

      1090       1100       1110       1120       1130       1140 
SNLLTAVGSS TRYSLTELNM AGCNKLTDQT LFFLRRIANV TLIDLRGCKQ ITRKACEHFI 

      1150       1160 
SDLSINSLYC LSDEKLIQKI S 

P59997 in FASTA format

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