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UniProtKB/Swiss-Prot entry P59796

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GPX6_HUMAN
Primary accession number P59796
Secondary accession number Q4PJ17
Integrated into Swiss-Prot on August 4, 2003
Sequence was last modified on February 26, 2008 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 43)
Name and origin of the protein
Protein name Glutathione peroxidase 6 [Precursor]
Synonym EC 1.11.1.9
Gene name
Name: GPX6
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
DOI=10.1126/science.1083516; PubMed=12775843 [NCBI, ExPASy, EBI, Israel, Japan]
Kryukov G.V., Castellano S., Novoselov S.V., Lobanov A.V., Zehtab O., Guigo R., Gladyshev V.N.;
"Characterization of mammalian selenoproteomes.";
Science 300:1439-1443(2003).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LEU-6; LEU-13; HIS-53; HIS-58; ASN-72; ASP-136; MET-140; SER-157; GLY-161 AND ALA-188.
Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N., Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY324826; AAP85543.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ088982; AAY68223.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_874360.1; -.
UniGene Hs.448570
3D structure databases
ModBase P59796.
Protein family/group databases
PeroxiBase 3605; HsGPx06.
Polymorphism databases
NIEHS-SNPs GPX6.
Organism-specific databases
H-InvDB HIX0032860; -.
HGNC HGNC:4558; GPX6.
GenAtlas GPX6.
MIM 607913; gene. [NCBI / EBI]
PharmGKB PA28954; -.
GeneCards P59796.
Gene expression databases
CleanEx HS_GPX6; -.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0004602; Molecular function: glutathione peroxidase activity (inferred from electronic annotation from InterPro).
GO:0008430; Molecular function: selenium binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006979; Biological process: response to oxidative stress (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000889; Glut_peroxidase.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.
Gene3D G3DSA:3.40.30.10; Thioredoxin_fold; 1.
PANTHER PTHR11592; Glut_peroxidase; 1.
Pfam PF00255; GSHPx; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000303; Glutathion_perox; 1.
PRINTS PR01011; GLUTPROXDASE.
PROSITE PS00460; GLUTATHIONE_PEROXID_1; 1.
PS00763; GLUTATHIONE_PEROXID_2; 1.
PS51355; GLUTATHIONE_PEROXID_3; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P59796.
Genome annotation databases
Ensembl ENSG00000198704; Homo sapiens. [Contig view]
GeneID 257202; -.
KEGG hsa:257202; -.
Phylogenomic databases
HOGENOM P59796; -.
HOVERGEN P59796; -.
Other
DrugBank DB00143; Glutathione.
NextBio 92965; -.
SOURCE GPX6; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Oxidoreductase; Peroxidase; Polymorphism; Secreted; Selenium; Selenocysteine; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    19  19     Potential. 
CHAIN   20   221  202     Glutathione peroxidase 6. PRO_0000013081
ACT_SITE   73    73        By similarity. 
NON_STD   73    73        Selenocysteine. 
VARIANT   6     6  1     Q -> L. VAR_025249 
VARIANT   13    13  1     F -> L. VAR_025250 
VARIANT   53    53  1     Y -> H. VAR_025251 
VARIANT   58    58  1     Q -> H. VAR_025252 
VARIANT   72    72  1     Y -> N. VAR_025253 
VARIANT   136   136  1     E -> D. VAR_025254 
VARIANT   140   140  1     V -> M. VAR_025255 
VARIANT   157   157  1     P -> S. VAR_025256 
VARIANT   161   161  1     D -> G. VAR_025257 
VARIANT   188   188  1     V -> A. VAR_025258 
Sequence information
Length: 221 AA [This is the length of the unprocessed precursor] Molecular weight: 24971 Da [This is the MW of the unprocessed precursor] CRC64: E9B48AF5F17C3FDD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MFQQFQASCL VLFFLVGFAQ QTLKPQNRKV DCNKGVTGTI YEYGALTLNG EEYIQFKQFA 

        70         80         90        100        110        120 
GKHVLFVNVA AYUGLAAQYP ELNALQEELK NFGVIVLAFP CNQFGKQEPG TNSEILLGLK 

       130        140        150        160        170        180 
YVCPGSGFVP SFQLFEKGDV NGEKEQKVFT FLKNSCPPTS DLLGSSSQLF WEPMKVHDIR 

       190        200        210        220 
WNFEKFLVGP DGVPVMHWFH QAPVSTVKSD ILEYLKQFNT H
P59796 in FASTA format

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