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UniProtKB/Swiss-Prot entry P57008

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHAS_NEIMA
Primary accession number P57008
Secondary accession number A1IPI2
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on December 1, 2000 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 48)
Name and origin of the protein
Protein name Aspartate-semialdehyde dehydrogenase
Synonyms ASA dehydrogenase
ASADH
EC 1.2.1.11
Gene name
Name: asd
OrderedLocusNames: NMA0351
From
Neisseria meningitidis serogroup A [TaxID: 65699] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Neisseria.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Z2491 / Serogroup A / Serotype 4A;
DOI=10.1038/35006655; PubMed=10761919 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M., Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M., Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K., Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A., Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G., Barrell B.G.;
"Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491.";
Nature 404:502-506(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL157959; CAM07651.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D82031; D82031.
3D structure databases
HSSP P00353; 1BRM. [HSSP ENTRY / PDB]
SMR P57008; 1-369.
ModBase P57008.
Enzyme and pathway databases
BioCyc NMEN122587:NMA0351-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0004073; Molecular function: aspartate-semialdehyde dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0046983; Molecular function: protein dimerization activity (inferred from electronic annotation from InterPro).
GO:0019877; Biological process: diaminopimelate biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000319; Asp-semialdehyde_DHase_CS.
IPR011534; Asp_ADH_proteob.
IPR012080; Asp_semialdehyde_DHase.
IPR016040; NAD(P)-bd.
IPR000534; Semialdehyde_DHase_NAD-bd.
IPR012280; Semialdhyde_DHase_C.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01118; Semialdhyde_dh; 1.
PF02774; Semialdhyde_dhC; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000148; ASA_dh; 1.
TIGRFAMs TIGR01745; asd_gamma; 1.
PROSITE PS01103; ASD; 1.
ProtoNet P57008.
Genome annotation databases
GenomeReviews AL157959_GR; NMA0351.
KEGG nma:NMA0351; -.
Phylogenomic databases
HOGENOM P57008; -.
Genome annotation databases
CMR P57008; NMA0351.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Diaminopimelate biosynthesis; Lysine biosynthesis; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   371  371     Aspartate-semialdehyde dehydrogenase. PRO_0000141384
ACT_SITE   135   135        Acyl-thioester intermediate (By similarity). 
Sequence information
Length: 371 AA [This is the length of the unprocessed precursor] Molecular weight: 40044 Da [This is the MW of the unprocessed precursor] CRC64: B419F887BF39B0E8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKVGFVGWRG MVGSVLMQRM KEENDFAHIP EAFFFTTSNV GGAAPDFGQA AKTLLDANDV 

        70         80         90        100        110        120 
AELAKMDIIV TCQGGDYTKS VFQPLRDSGW NGYWVDAASS LRMKDDAIIV LDPVNRNVID 

       130        140        150        160        170        180 
NGLKNGVKNY IGGNCTVSLM LMALGGLFQN DLVEWATSMT YQAASGAGAK NMRELISGMG 

       190        200        210        220        230        240 
AIHAKVADEL ADPSSAILDI DRKVSDFLRS EDYPKANFGV PLAGSLIPWI DVDLGNGQSK 

       250        260        270        280        290        300 
EEWKGGVETN KILGRSDNPT VIDGLCVRIG SMRCHSQALT LKLKKDLPVS EIEAILAGAN 

       310        320        330        340        350        360 
DWVKVIPNEK EASIHELTPA KVTGTLSVPV GRIRKLEMGG EYISAFTVGD QLLWGAAEPL 

       370 
RRVLRIVLGS L
P57008 in FASTA format

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