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UniProtKB/Swiss-Prot entry P56465

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_HELPY
Primary accession number P56465
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on July 15, 1998 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 57)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: HP_0581
From
Helicobacter pylori (Campylobacter pylori) [TaxID: 210] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700392 / 26695;
DOI=10.1038/41483; PubMed=9252185 [NCBI, ExPASy, EBI, Israel, Japan]
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
"The complete genome sequence of the gastric pathogen Helicobacter pylori.";
Nature 388:539-547(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000511; AAD07635.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E64592; E64592.
RefSeq NP_207376.1; -.
3D structure databases
HSSP P05020; 1J79. [HSSP ENTRY / PDB]
ModBase P56465.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00219; -; 1.
PBIL [Tree]
InterPro IPR006992; Amidohydro_2.
IPR004721; DHOdimr.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF04909; Amidohydro_2; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001237; DHOdimr; 1.
TIGRFAMs TIGR00856; pyrC_dimer; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS P56465.
ProtoNet P56465.
Genome annotation databases
GeneID 900032; -.
GenomeReviews AE000511_GR; HP_0581.
KEGG hpy:HP0581; -.
NMPDR fig|85962.1.peg.574; -.
TIGR HP_0581; -.
Phylogenomic databases
HOGENOM P56465; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   339  339     Dihydroorotase. PRO_0000147208
METAL   12    12        Zinc 1 (By similarity). 
METAL   14    14        Zinc 1 (By similarity). 
METAL   94    94        Zinc 1; via carbamate group (By similarity). 
METAL   94    94        Zinc 2; via carbamate group (By similarity). 
METAL   133   133        Zinc 2 (By similarity). 
METAL   167   167        Zinc 2 (By similarity). 
METAL   239   239        Zinc 1 (By similarity). 
MOD_RES   94    94        N6-carboxylysine (By similarity). 
Sequence information
Length: 339 AA [This is the length of the unprocessed precursor] Molecular weight: 37883 Da [This is the MW of the unprocessed precursor] CRC64: DC0186A914FA11E4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEITLFDPID AHLHVRENAL LKAVLGYSSE PFSAAVIMPN LSKPLIDTPT TLEYEEEILN 

        70         80         90        100        110        120 
HSSNFKPLMS LYFNDGLTLE ELQCAKEKGV RFLKLYPKGM TTNAQNGTSD LLGEKTLEVL 

       130        140        150        160        170        180 
ENAQKLGFIL CIHAEQTGFC LDKEFLCHSV LETFALSFPK LKIIIEHLSD WRSIALIEKH 

       190        200        210        220        230        240 
DNLYATLTLH HISMTLDDLL GGSLNPHCFC KPLIKTKKDQ ERLLSLALKA HPKISFGSDS 

       250        260        270        280        290        300 
APHFISKKHS ANIPAGIFSA PILLPALCEL FEKHNALENL QAFISDNAKT IYGLENLPSK 

       310        320        330 
KARLSKKPFM IPTHTLCLNE KIAILRGGET LSWNLQEIA
P56465 in FASTA format

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