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UniProtKB/Swiss-Prot entry P46806


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHOM_MYCLE
Primary accession number P46806
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 54)
Name and origin of the protein
Protein name Homoserine dehydrogenase
Synonyms HDH
EC 1.1.1.3
Gene name
Name: hom
OrderedLocusNames: ML1129
From
Mycobacterium leprae [TaxID: 1769] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Smith D.R., Robison K.;
Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=TN;
DOI=10.1038/35059006; PubMed=11234002 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G.;
"Massive gene decay in the leprosy bacillus.";
Nature 409:1007-1011(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U15186; AAA63101.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL583920; CAC31510.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T09992; T09992.
RefSeq NP_301823.1; -.
3D structure databases
ModBase P46806.
Enzyme and pathway databases
BioCyc MLEP272631:ML1129-MON; -.
Organism-specific databases
Leproma ML1129; -.
Family and domain databases
InterPro IPR002912; ACT_bd.
IPR005106; Asp/hSer_DHase_NAD-bd.
IPR016204; hSer_DHase.
IPR001342; hSer_DHase_cat.
Graphical view of domain structure.
Pfam PF01842; ACT; 1.
PF00742; Homoserine_dh; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000098; Homoser_dehydrog; 1.
PROSITE PS01042; HOMOSER_DHGENASE; 1.
BLOCKS P46806.
Genome annotation databases
GeneID 910223; -.
GenomeReviews AL450380_GR; ML1129.
KEGG mle:ML1129; -.
NMPDR fig|272631.1.peg.695; -.
Phylogenomic databases
HOGENOM P46806; -.
Genome annotation databases
CMR P46806; ML1129.
Other
ProtoNet P46806.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Isoleucine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Threonine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   441  441     Homoserine dehydrogenase. PRO_0000066701
DOMAIN   355   433  79     ACT. 
NP_BIND   13    20  8     NADP (By similarity). 
ACT_SITE   207   207        Proton donor (Potential). 
BINDING   107   107        NADP (By similarity). 
BINDING   192   192        Substrate (By similarity). 
Sequence information
Length: 441 AA [This is the length of the unprocessed precursor] Molecular weight: 45606 Da [This is the MW of the unprocessed precursor] CRC64: 41EEC1939A5FD0F8 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MFSDERTVGV AVLGLGNVGS EVVRIIEGSA DDLAARIGAP LMLRGIGVRR VAVDRGVPVD 

        70         80         90        100        110        120 
LLTDNIEELV SRADVDIVVE VMGPVELSRK AILSALEHGK SVVTANKALL AASTGELAQA 

       130        140        150        160        170        180 
AESAHVDLYF EAAVAGAIPV IRPLTQSLAG DTVLRVAGIV NGTTNYILSA MDSTGADYDS 

       190        200        210        220        230        240 
ALAGARALGY AEADPTADVE GHDAAAKAAI LASIAFHTRV TADDVYREGI TKITPADFVS 

       250        260        270        280        290        300 
ARALGCTIKL LFICERITAA DGQQRVSARV YPALVPMSHP LATVSGAFNA VVVEAEAAGR 

       310        320        330        340        350        360 
LMFYGQGAGG APTASAVTGD LVMAARNRVL GSRGPKESKY AQLPMETIGF ISTRYYVSMN 

       370        380        390        400        410        420 
VADKPGVLSG VAAEFAKREV SIAEVRQEGV VDDGGRRVGA RIVVVTHGAT DAALSETVDA 

       430        440 
LADLDVVQGV TSVLRLEGIS L 

P46806 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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NPSA logo NPSA Sequence analysis tools

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