[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=DSM 405 / IFO 15313 / YP-T; PubMed=7516791 [NCBI, ExPASy, EBI, Israel, Japan] Ghim S.Y., Nielsen P., Neuhard J.; "Molecular characterization of pyrimidine biosynthesis genes from the thermophile Bacillus caldolyticus."; Microbiology 140:479-491(1994).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-61. STRAIN=DSM 405 / IFO 15313 / YP-T; PubMed=8206848 [NCBI, ExPASy, EBI, Israel, Japan] Ghim S.Y., Neuhard J.; "The pyrimidine biosynthesis operon of the thermophile Bacillus caldolyticus includes genes for uracil phosphoribosyltransferase and uracil permease."; J. Bacteriol. 176:3698-3707(1994).

Comments

CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6 .
SUBUNIT: Homotrimer.
SIMILARITY: Belongs to the ATCase/OTCase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X73308; CAA51736.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X76083; CAA53698.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

I40166; I40166.

3D structure databases

HSSP

P77918; 1ML4. [HSSP ENTRY / PDB]

ModBase

P41008.

Ontologies

GO:0004070;	Molecular function: aspartate carbamoyltransferase activity (inferred from electronic annotation from HAMAP).
GO:0006221;	Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00001; -; 1.
PBIL [Tree]

InterPro

IPR006130; Asp/Orn_carbamoyltranf.
IPR006132; Asp/Orn_carbamoyltranf_P_bd.
IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
IPR002082; Aspartate_carbamoyltransf_euk.
Graphical view of domain structure.

Pfam

PF00185; OTCace; 1.
PF02729; OTCace_N; 1.
Pfam graphical view of domain structure.

PRINTS

PR00100; AOTCASE.
PR00101; ATCASE.

TIGRFAMs

TIGR00670; asp_carb_tr; 1.

PROSITE

PS00097; CARBAMOYLTRANSFERASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Pyrimidine biosynthesis; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 308`	`308`		`Aspartate carbamoyltransferase.`	`PRO_0000113091`

Sequence information

Length: 308 AA [This is the length of the unprocessed precursor]

Molecular weight: 34871 Da [This is the MW of the unprocessed precursor]

CRC64: FAAA34EA1620291A [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTHLFALSEL PLDEIHRLLD EAERFRSGRI WRPAAPMYVA NLFFEPSTRT KCSFEMAERK 

        70         80         90        100        110        120 
LGLHVIPFDP ERSSVQKGET LYDTVRTLEA IGVDAVVIRH HEDAYFEALR HAVGIPIINA 

       130        140        150        160        170        180 
GDGCGHHPTQ SLLDLLTIRQ EFGAFTGLTV AIIGDIRHSR VARSNAEVLT RLGANVLFSG 

       190        200        210        220        230        240 
PEEWKDETNP YGTYVEVDEA IARADVVMLL RIQHERHAET MGLTKEEYHA RYGLTLERAR 

       250        260        270        280        290        300 
RMKSGAIILH PAPVNRGVEI ASELVEAKAS RIFKQMENGV YVRMAVLKRA MEGRMEHGRM 


AEKWHVVQ

P41008 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools