[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1016/0169-328X(90)90045-F; PubMed=2176709 [NCBI, ExPASy, EBI, Israel, Japan] Hara Y., Battey J., Gainer H.; "Structure of mouse vasopressin and oxytocin genes."; Brain Res. Mol. Brain Res. 8:319-324(1990).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=ILS, and ISS; DOI=10.1007/s00335-001-1001-x; PubMed=11471062 [NCBI, ExPASy, EBI, Israel, Japan] Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.; "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."; Mamm. Genome 12:657-663(2001).

Comments

FUNCTION: Neurophysin 1 specifically binds oxytocin.
FUNCTION: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
SIMILARITY: Belongs to the vasopressin/oxytocin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M88355; AAC42024.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF483508; AAL90782.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF483509; AAL90783.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

A43755; A43755.

NP_035155.1; -.

3D structure databases

HSSP

P01175; 1L5C. [HSSP ENTRY / PDB]

SMR

P35454; 32-123.

ModBase

P35454.

Organism-specific databases

MGI

MGI:97453; Oxt.

Gene expression databases

ArrayExpress

P35454; -.

CleanEx

MM_OXT; -.

GermOnline

ENSMUSG00000027301; Mus musculus.

Family and domain databases

InterPro

IPR000981; Neurhyp_horm.
IPR016321; Nonapeptide_hormone_prcur.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.9.10; Neurhyp_horm; 1.

Pfam

PF00220; Hormone_4; 1.
PF00184; Hormone_5; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF001815; Nonapeptide_hormone_precursor; 1.

PRINTS

PR00831; NEUROPHYSIN.

ProDom

PD001676; Neurhyp_horm; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00003; NH; 1.
SMART graphical view of domain structure.

PROSITE

PS00264; NEUROHYPOPHYS_HORM; 1.

BLOCKS

P35454.

Genome annotation databases

Ensembl

ENSMUSG00000027301; Mus musculus. [Contig view]

GeneID

18429; -.

KEGG

mmu:18429; -.

Phylogenomic databases

HOGENOM

P35454; -.

HOVERGEN

P35454; -.

Other

Oxt; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amidation; Cleavage on pair of basic residues; Hormone; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 19`	`19`	`By similarity.`
`PEPTIDE`	`20 28`	`9`	`Oxytocin.`	`PRO_0000020497`
`CHAIN`	`32 125`	`94`	`Neurophysin 1.`	`PRO_0000020498`
`MOD_RES`	`28 28`		`Glycine amide (By similarity).`
`DISULFID`	`20 25`		`By similarity.`
`DISULFID`	`41 85`		`By similarity.`
`DISULFID`	`44 58`		`By similarity.`
`DISULFID`	`52 75`		`By similarity.`
`DISULFID`	`59 65`		`By similarity.`
`DISULFID`	`92 104`		`By similarity.`
`DISULFID`	`98 116`		`By similarity.`
`DISULFID`	`105 110`		`By similarity.`

Sequence information

Length: 125 AA [This is the length of the unprocessed precursor]

Molecular weight: 12851 Da [This is the MW of the unprocessed precursor]

CRC64: 96D3135EBBA2436E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDMRK CLPCGPGGKG RCFGPSICCA 

        70         80         90        100        110        120 
DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA TGICCSPDGC RTDPACDPES 


AFSER

P35454 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools