[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND MYRISTOYLATION AT GLY-2. DOI=10.1083/jcb.116.2.405; PubMed=1530946 [NCBI, ExPASy, EBI, Israel, Japan] Wice B.M., Gordon J.I.; "A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin."; J. Cell Biol. 116:405-422(1992).
[2]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B). TISSUE=Colon adenocarcinoma; PubMed=11961095 [NCBI, ExPASy, EBI, Israel, Japan] Iglesias J.M., Morgan R.O., Jenkins N.A., Copeland N.G., Gilbert D.J., Fernandez M.-P.; "Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins."; Mol. Biol. Evol. 19:608-618(2002).

Comments

SUBCELLULAR LOCATION: Cell membrane. Note=Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes.

ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name	A
Synonyms	Anx13A
Isoform ID	P27216-1
This is the isoform sequence displayed in this entry.

Name	B
Synonyms	Anx13B
Isoform ID	P27216-2
Features which should be applied to build the isoform sequence: VSP_000291.

TISSUE SPECIFICITY: Gut specific.
DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid.
SIMILARITY: Belongs to the annexin family.
SIMILARITY: Contains 4 annexin repeats.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Z11502; CAA77578.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ306450; CAC34622.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A41733; LUHUIS.

RefSeq

NP_001003954.1; -.
NP_004297.2; -.

UniGene

Hs.181107

3D structure databases

HSSP

P13214; 1ANN. [HSSP ENTRY / PDB]

ModBase

P27216.

Organism-specific databases

HGNC:536; ANXA13.

602573; gene. [NCBI / EBI]

PharmGKB

PA24826; -.

GeneCards

P27216.

Gene expression databases

ArrayExpress

P27216; -.

CleanEx

HS_ANXA13; -.

GermOnline

ENSG00000104537; Homo sapiens.

Ontologies

GO:0005886;	Cellular component: plasma membrane (non-traceable author statement from UniProtKB).
GO:0005544;	Molecular function: calcium-dependent phospholipid binding (non-traceable author statement from UniProtKB).
GO:0030154;	Biological process: cell differentiation (non-traceable author statement from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR001464; Annexin.
IPR009166; AnnexinXIII.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.220.10; Annexin; 4.

PANTHER

PTHR10502; Annexin; 1.

Pfam

PF00191; Annexin; 4.
Pfam graphical view of domain structure.

PRINTS

PR00196; ANNEXIN.
PR01811; ANNEXINXIII.

ProDom

PD000143; Annexin; 4.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00335; ANX; 4.
SMART graphical view of domain structure.

PROSITE

PS00223; ANNEXIN; 3.

BLOCKS

P27216.

Genome annotation databases

Ensembl

ENSG00000104537; Homo sapiens. [Contig view]

GeneID

312; -.

KEGG

hsa:312; -.

Phylogenomic databases

HOGENOM

P27216; -.

HOVERGEN

P27216; -.

Other

SOURCE

ANXA13; Homo sapiens.

ProtoNet

P27216.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Annexin; Calcium; Calcium/phospholipid-binding; Cell membrane; Lipoprotein; Membrane; Myristate; Repeat.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed.`
`CHAIN`	`2 316`	`315`	`Annexin A13.`	`PRO_0000067514`
`REPEAT`	`23 83`	`61`	`Annexin 1.`
`REPEAT`	`95 155`	`61`	`Annexin 2.`
`REPEAT`	`179 239`	`61`	`Annexin 3.`
`REPEAT`	`254 314`	`61`	`Annexin 4.`
`LIPID`	`2 2`		`N-myristoyl glycine.`
`VAR_SEQ`	`5 5`		`H -> HSQSYTLSEGSQQLPKGDSQPSTVVQPLSHPSRNGEP` `EAPQP (in isoform B).`	`VSP_000291`
`CONFLICT`	`112 112`		`F -> V (in Ref. 2; CAC34622).`

Sequence information

Length: 316 AA [This is the length of the unprocessed precursor]

Molecular weight: 35463 Da [This is the MW of the unprocessed precursor]

CRC64: C2DA06B370A95F87 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGNRHAKASS PQGFDVDRDA KKLNKACKGM GTNEAAIIEI LSGRTSDERQ QIKQKYKATY 

        70         80         90        100        110        120 
GKELEEVLKS ELSGNFEKTA LALLDRPSEY AARQLQKAMK GLGTDESVLI EFLCTRTNKE 

       130        140        150        160        170        180 
IIAIKEAYQR LFDRSLESDV KGDTSGNLKK ILVSLLQANR NEGDDVDKDL AGQDAKDLYD 

       190        200        210        220        230        240 
AGEGRWGTDE LAFNEVLAKR SYKQLRATFQ AYQILIGKDI EEAIEEETSG DLQKAYLTLV 

       250        260        270        280        290        300 
RCAQDCEDYF AERLYKSMKG AGTDEETLIR IVVTRAEVDL QGIKAKFQEK YQKSLSDMVR 

       310 
SDTSGDFRKL LVALLH

P27216 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools