ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P21781


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name FGF7_HUMAN
Primary accession number P21781
Secondary accession numbers None
Integrated into Swiss-Prot on May 1, 1991
Sequence was last modified on May 1, 1991 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 78)
Name and origin of the protein
Protein name Keratinocyte growth factor [Precursor]
Synonyms KGF
Fibroblast growth factor 7
FGF-7
Heparin-binding growth factor 7
HBGF-7
Gene name
Name: FGF7
Synonyms: KGF
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 32-50.
PubMed=2475908 [NCBI, ExPASy, EBI, Israel, Japan]
Finch P.W., Rubin J.S., Miki T., Ron D., Aaronson S.A.;
"Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth.";
Science 245:752-755(1989).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1664700 [NCBI, ExPASy, EBI, Israel, Japan]
Aaronson S.A., Bottaro D.P., Miki T., Ron D., Finch P.W., Fleming T.P., Ahn J., Taylor W.G., Rubin J.S.;
"Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity.";
Ann. N. Y. Acad. Sci. 638:62-77(1991).
[3]
PROTEIN SEQUENCE OF 32-44.
PubMed=2915979 [NCBI, ExPASy, EBI, Israel, Japan]
Rubin J.S., Osada H., Finch P.W., Taylor W.G., Rudikoff S., Aaronson S.A.;
"Purification and characterization of a newly identified growth factor specific for epithelial cells.";
Proc. Natl. Acad. Sci. U.S.A. 86:802-806(1989).
[4]
INTERACTION WITH FGFBP1.
DOI=10.1038/sj.onc.1208560; PubMed=15806171 [NCBI, ExPASy, EBI, Israel, Japan]
Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.;
"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.";
Oncogene 24:5269-5277(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M60828; AAA63210.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S81661; AAB21431.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A36301; A36301.
B46289; B46289.
RefSeq NP_002000.1; -.
UniGene Hs.567268
3D structure databases
HSSP Q02195; 1QQK. [HSSP ENTRY / PDB]
SMR P21781; 63-194.
ModBase P21781.
Protein-protein interaction databases
DIP DIP:4010N; -.
Enzyme and pathway databases
Reactome REACT_9470; Signaling by FGFR.
Organism-specific databases
H-InvDB HIX0008074; -.
HIX0012227; -.
HIX0035058; -.
HIX0041064; -.
HIX0058650; -.
HIX0058651; -.
HIX0058652; -.
HGNC HGNC:3685; FGF7.
GenAtlas FGF7.
MIM 148180; gene. [NCBI / EBI]
PharmGKB PA28124; -.
GeneCards P21781.
Gene expression databases
ArrayExpress P21781; -.
CleanEx HS_FGF7; -.
GermOnline ENSG00000140285; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from experiment from Reactome).
GO:0008083; Molecular function: growth factor activity (traceable author statement from ProtInc).
GO:0008544; Biological process: epidermis development (traceable author statement from ProtInc).
GO:0008543; Biological process: fibroblast growth factor receptor signaling pathway (inferred from experiment from Reactome).
GO:0008284; Biological process: positive regulation of cell proliferation (traceable author statement from ProtInc).
GO:0009611; Biological process: response to wounding (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR002209; GF_heparin_bd.
IPR002348; IL1_HBGF.
Graphical view of domain structure.
PANTHER PTHR11486; IL1_HBGF; 1.
Pfam PF00167; FGF; 1.
Pfam graphical view of domain structure.
PRINTS PR00263; HBGFFGF.
PR00262; IL1HBGF.
ProDom PD000831; IL1_HBGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00442; FGF; 1.
SMART graphical view of domain structure.
PROSITE PS00247; HBGF_FGF; 1.
BLOCKS P21781.
Genome annotation databases
Ensembl ENSG00000140285; Homo sapiens. [Contig view]
GeneID 2252; -.
KEGG hsa:2252; -.
Phylogenomic databases
HOGENOM P21781; -.
HOVERGEN P21781; -.
Other
DrugBank DB00039; Palifermin.
LinkHub P21781; -.
SOURCE FGF7; Homo sapiens.
ProtoNet P21781.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Glycoprotein; Growth factor; Mitogen; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
SIGNAL   1    31  31      
CHAIN   32   194  163     Keratinocyte growth factor. PRO_0000008965
CARBOHYD   45    45        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 194 AA [This is the length of the unprocessed precursor] Molecular weight: 22509 Da [This is the MW of the unprocessed precursor] CRC64: B19192474E6049E2 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE RHTRSYDYME 

        70         80         90        100        110        120 
GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA 

       130        140        150        160        170        180 
MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK 

       190 
KEQKTAHFLP MAIT 

P21781 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by br flag LNCC Brazil Mirror sites: Australia  Canada  China  Korea  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!