NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0092-8674(90)90265-G; PubMed=2393904 [NCBI, ExPASy, EBI, Israel, Japan]
Koslowsky D.J., Bhat G., Jayarama Perrollaz A.L., Feagin J.E., Stuart K.;
"The MURF3 gene of T. brucei contains multiple domains of extensive editing and is homologous to a subunit of NADH dehydrogenase.";
Cell 62:901-911(1990).

Comments

FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.
CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: Belongs to the complex I 49 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M55645; -; NOT_ANNOTATED_CDS; mRNA.

[EMBL / GenBank / DDBJ]

PIR

A35693; A35693.

3D structure databases

ModBase

P21301.

Ontologies

GO:0005746;	Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0008137;	Molecular function: NADH dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
GO:0022900;	Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810;	Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR014029; NADH-UbQ_OxRdtase_49kDa_CS.
IPR001135; NADH_UbQ_OxRdtase_49kDa.
Graphical view of domain structure.

Pfam

PF00346; Complex1_49kDa; 1.
Pfam graphical view of domain structure.

PROSITE

PS00535; COMPLEX1_49K; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Electron transport; Mitochondrion; NAD; Oxidoreductase; Respiratory chain; Transport; Ubiquinone.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 386`	`386`		`NADH-ubiquinone oxidoreductase 49 kDa subunit homolog.`	`PRO_0000118594`

Sequence information

Length: 386 AA [This is the length of the unprocessed precursor]

Molecular weight: 45098 Da [This is the MW of the unprocessed precursor]

CRC64: 448F5D52DC572071 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLFLVVFLHL YRFTFGPQHP AAHGVLCCLL YFCGEFIVYI DCIIGYLHRG TEKLCEYKSV 

        70         80         90        100        110        120 
EQCLPYFDRL DYVSVCCNEH LLSLCFEYML RCCLSLRCAF MRLLIVEFTR SFNGLLCISC 

       130        140        150        160        170        180 
MVLDLGCLSP LLWSFEERDK LMTFFDLCCG CRMHLAFMVL LGILDDFVFG FVDFLLLLII 

       190        200        210        220        230        240 
SCLFVMDCYD LLFVGNRLFY LRLRGLSFFD LYDLVFNSLS GVLSRSLGMV WDCRLFSCYE 

       250        260        270        280        290        300 
LYFMFCYDYC FCFIGDAFDR LFLRLFDMRM SLLICKQCFF VGFFVFGFVC LFDYLYCDIT 

       310        320        330        340        350        360 
IETIIMLFYS LWCCCLPGIS FACVEHPKGE YCLLLCFCVG LCSRLRLRCA DFLHICLLDV 

       370        380 
CLRGFLLHDL VAVLGNIDVV FGSVDR

P21301 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools