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UniProtKB/Swiss-Prot entry P20692


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TYRA_BACSU
Primary accession number P20692
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1991
Sequence was last modified on August 29, 2003 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 68)
Name and origin of the protein
Protein name Prephenate dehydrogenase
Synonyms PDH
EC 1.3.1.12
Gene name
Name: tyrA
OrderedLocusNames: BSU22610
From
Bacillus subtilis [TaxID: 1423] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
Protein existence 4: Predicted;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(86)90394-X; PubMed=3106153 [NCBI, ExPASy, EBI, Israel, Japan]
Henner D.J., Band L., Flaggs G., Chen E.;
"The organization and nucleotide sequence of the Bacillus subtilis hisH, tyrA and aroE genes.";
Gene 49:147-152(1986).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=168;
DOI=10.1038/36786; PubMed=9384377 [NCBI, ExPASy, EBI, Israel, Japan]
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.;
"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.";
Nature 390:249-256(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M80245; AAA20868.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z99115; CAB14177.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_390142.1; -.
3D structure databases
ModBase P20692.
Enzyme and pathway databases
BioCyc BSUB224308:BSU2260-MON; -.
Organism-specific databases
SubtiList BG10293; tyrA. [Micado]
Ontologies
GO
GO:0008977; Molecular function: prephenate dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002912; ACT_bd.
IPR003099; Prephen_DHase.
Graphical view of domain structure.
PANTHER PTHR21363; Prephen_DH; 1.
Pfam PF01842; ACT; 1.
PF02153; PDH; 1.
Pfam graphical view of domain structure.
PROSITE PS51176; PDH_ADH; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P20692.
ProtoNet P20692.
Genome annotation databases
GeneID 939013; -.
GenomeReviews AL009126_GR; BSU22610.
KEGG bsu:BSU22610; -.
NMPDR fig|224308.1.peg.2265; -.
Phylogenomic databases
HOGENOM P20692; -.
Other
LinkHub P20692; -.
Genome annotation databases
CMR P20692; BSU22610.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NAD; Oxidoreductase; Tyrosine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   371  371     Prephenate dehydrogenase. PRO_0000119192
DOMAIN   6   295  290     Prephenate/arogenate dehydrogenase. 
DOMAIN   299   371  73     ACT. 
NP_BIND   7    37  31     NAD (Potential). 
Sequence information
Length: 371 AA [This is the length of the unprocessed precursor] Molecular weight: 41434 Da [This is the MW of the unprocessed precursor] CRC64: 9254360B94526C00 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNQMKDTILL AGLGLIGGSI ALAIKKNHPG KRIIGIDISD EQAVAALKLG VIDDRADSFI 

        70         80         90        100        110        120 
SGVKEAATVI IATPVEQTLV MLEELAHSGI EHELLITDVG STKQKVVDYA DQVLPSRYQF 

       130        140        150        160        170        180 
VGGHPMAGSH KSGVAAAKEF LFENAFYILT PGQKTDKQAV EQLKNLLKGT NAHFVEMSPE 

       190        200        210        220        230        240 
EHDGVTSVIS HFPHIVAASL VHQTHHSENL YPLVKRFAAG GFRDITRIAS SSPAMWRDIL 

       250        260        270        280        290        300 
LHNKDKILDR FDEWIREIDK IRTYVEQEDA ENLFRYFKTA KDYRDGLPLR QKGAIPAFYD 

       310        320        330        340        350        360 
LYVDVPDHPG VISEITAILA AERISITNIR IIETREDING ILRISFQSDD DRKRAEQCIE 

       370 
ARAEYETFYA D 

P20692 in FASTA format

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