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UniProtKB/Swiss-Prot entry P20049


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TYR1_YEAST
Primary accession number P20049
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1991
Sequence was last modified on October 1, 1994 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 66)
Name and origin of the protein
Protein name Prephenate dehydrogenase [NADP+]
Synonyms PRDH
EC 1.3.1.13
Gene name
Name: TYR1
OrderedLocusNames: YBR166C
ORFNames: YBR1218
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(89)90422-8; PubMed=2697638 [NCBI, ExPASy, EBI, Israel, Japan]
Mannhaupt G., Stucka R., Pilz U., Schwarzlose C., Feldmann H.;
"Characterization of the prephenate dehydrogenase-encoding gene, TYR1, from Saccharomyces cerevisiae.";
Gene 85:303-311(1989).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=7813418 [NCBI, ExPASy, EBI, Israel, Japan]
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.;
"Complete DNA sequence of yeast chromosome II.";
EMBO J. 13:5795-5809(1994).
[3]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z36035; CAA85127.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S46037; S46037.
RefSeq NP_009725.1; -.
3D structure databases
ModBase P20049.
Protein-protein interaction databases
DIP DIP:4627N; -.
IntAct P20049; -.
Organism-specific databases
CYGD YBR166c; -.
SGD S000000370; TYR1.
Yeast-GFP YBR166C.
Gene expression databases
GermOnline YBR166C; Saccharomyces cerevisiae.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from SGD).
GO:0042802; Molecular function: identical protein binding (inferred from physical interaction from IntAct).
GO:0006570; Biological process: tyrosine metabolic process (non-traceable author statement from SGD).
QuickGo view.
Family and domain databases
InterPro IPR003099; Prephen_DHase.
IPR012385; Prephenate_DHase_fun.
Graphical view of domain structure.
PIRSF PIRSF036510; PDH_fung; 1.
PROSITE PS51176; PDH_ADH; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P20049.
ProtoNet P20049.
Proteomic databases
PeptideAtlas P20049; -.
Genome annotation databases
Ensembl YBR166C; Saccharomyces cerevisiae. [Contig view]
GeneID 852464; -.
GenomeReviews Y13134_GR; YBR166C.
KEGG sce:YBR166C; -.
NMPDR fig|4932.3.peg.431; -.
Phylogenomic databases
HOGENOM P20049; -.
Other
LinkHub P20049; -.
NextBio 971408; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase; Tyrosine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   452  452     Prephenate dehydrogenase [NADP+]. PRO_0000119208
DOMAIN   14   297  284     Prephenate/arogenate dehydrogenase. 
NP_BIND   14    43  30     NADP (Potential). 
CONFLICT   38    38        G -> S (in Ref. 1). 
CONFLICT   204   211        IKIYPWTL -> DKDSSLDS (in Ref. 1). 
CONFLICT   312   313        GN -> SD (in Ref. 1). 
CONFLICT   433   452        MIKTILSHSSDRSAAEKRNT -> DDKNHSESF (in Ref. 1). 
Sequence information
Length: 452 AA [This is the length of the unprocessed precursor] Molecular weight: 50923 Da [This is the MW of the unprocessed precursor] CRC64: D483B93ABBC8F8F4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVSEDKIEQW KATKVIGIIG LGDMGLLYAN KFTDAGWGVI CCDREEYYDE LKEKYASAKF 

        70         80         90        100        110        120 
ELVKNGHLVS RQSDYIIYSV EASNISKIVA TYGPSSKVGT IVGGQTSCKL PEIEAFEKYL 

       130        140        150        160        170        180 
PKDCDIITVH SLHGPKVNTE GQPLVIINHR SQYPESFEFV NSVMACLKSK QVYLTYEEHD 

       190        200        210        220        230        240 
KITADTQAVT HAAFLSMGSA WAKIKIYPWT LGVNKWYGGL ENVKVNISLR IYSNKWHVYA 

       250        260        270        280        290        300 
GLAITNPSAH QQILQYATSA TELFSLMIDN KEQELTDRLL KAKQFVFGKH TGLLLLDDTI 

       310        320        330        340        350        360 
LEKYSLSKSS IGNSNNCKPV PNSHLSLLAI VDSWFQLGID PYDHMICSTP LFRIFLGVSE 

       370        380        390        400        410        420 
YLFLKPGLLE QTIDAAIHDK SFIKDDLEFV ISAREWSSVV SFANFDIYKK QFQSVQKFFE 

       430        440        450 
PMLPEANLIG NEMIKTILSH SSDRSAAEKR NT 

P20049 in FASTA format

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