[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=2254258 [NCBI, ExPASy, EBI, Israel, Japan] Nordlund I., Powlowski J., Shingler V.; "Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600."; J. Bacteriol. 172:6826-6833(1990).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=BH; Takeo M., Maeda Y., Okada H., Miyama K., Mori K., Ike M., Fujita M.; Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catabolizes phenol, and some of its methylated derivatives. P0 is required for growth on phenol, but not for in vitro phenol hydroxylase activity.
CATALYTIC ACTIVITY: Phenol + NADPH + O₂ = catechol + NADP⁺ + H₂O.
COFACTOR: FAD.
COFACTOR: Fe(2+).
PATHWAY: Aromatic compound metabolism; phenol degradation .
SUBUNIT: The multicomponent enzyme phenol hydroxylase is formed by P0, P1, P2, P3, P4 and P5 polypeptides.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M60276; AAA25939.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
D28864; BAA06014.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

P19729.

Enzyme and pathway databases

BioCyc

MetaCyc:MON-12794; -.

Ontologies

GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0018662;	Molecular function: phenol 2-monooxygenase activity (inferred from electronic annotation from EC).
GO:0019439;	Biological process: aromatic compound catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR010353; Phenol_hyd_sub.
Graphical view of domain structure.

Pfam

PF06099; Phenol_hyd_sub; 1.
Pfam graphical view of domain structure.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Aromatic hydrocarbons catabolism; FAD; Flavoprotein; Iron; Monooxygenase; NADP; Oxidoreductase; Plasmid.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 92`	`92`		`Phenol hydroxylase P0 protein.`	`PRO_0000079940`

Sequence information

Length: 92 AA [This is the length of the unprocessed precursor]

Molecular weight: 10586 Da [This is the MW of the unprocessed precursor]

CRC64: 9893DFD3CAACB71E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTVTNTPTPT FDQLTRYIRV RSEPEAKFVE FDFAIGHPEL FVELVLPQDA FVKFCQHNRV 

        70         80         90 
VAMDEAMAKA VDDDMVKWRF GDVGRRLPKD PG

P19729 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools