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UniProtKB/Swiss-Prot entry P17177

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP27A_RABIT
Primary accession number P17177
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1990
Sequence was last modified on August 1, 1990 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 62)
Name and origin of the protein
Protein name Cytochrome P450 27, mitochondrial [Precursor]
Synonyms EC 1.14.13.15
Cytochrome P-450C27/25
Sterol 26-hydroxylase
Sterol 27-hydroxylase
Vitamin D(3) 25-hydroxylase
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
Gene name
Name: CYP27A1
Synonyms: CYP27
From
Oryctolagus cuniculus (Rabbit) [TaxID: 9986] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2722778 [NCBI, ExPASy, EBI, Israel, Japan]
Andersson S., Davis D.L., Dahlbaeck H., Joernvall H., Russell D.W.;
"Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.";
J. Biol. Chem. 264:8222-8229(1989).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
J04717; AAA31225.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A33813; A33813.
3D structure databases
HSSP P00189; 1SCC. [HSSP ENTRY / PDB]
ModBase P17177.
Ontologies
GO
GO:0031966; Cellular component: mitochondrial membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0047749; Molecular function: cholestanetriol 26-monooxygenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS P17177.
ProtoNet P17177.
Genome annotation databases
Ensembl ENSOCUG00000003377; Oryctolagus cuniculus. [Contig view]
Phylogenomic databases
HOVERGEN P17177; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Heme; Iron; Membrane; Metal-binding; Mitochondrion; Monooxygenase; NADP; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
TRANSIT   1    32  32     Mitochondrion (Probable). 
CHAIN   33   535  503     Cytochrome P450 27, mitochondrial. PRO_0000003620
REGION   387   401  15     Sterol-binding (Potential). 
METAL   480   480        Iron (heme axial ligand). 
MOD_RES   126   126        N6-acetyllysine (By similarity). 
MOD_RES   286   286        N6-acetyllysine (By similarity). 
Sequence information
Length: 535 AA [This is the length of the unprocessed precursor] Molecular weight: 60255 Da [This is the MW of the unprocessed precursor] CRC64: CC44B9820E2FCCC2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAALGCARLR WALLGPRVAG CGLCPQGARA KAAIPTALPA DEAAQAPGAG PGDRRRRRSL 

        70         80         90        100        110        120 
EELPRLGQLR FFYQAFVQGY LLHLHKLQVL NKARYGPMWV SYLGPQLFVN LASAPLVETV 

       130        140        150        160        170        180 
MRQEGKYPVR NDMQLWKEHR DHQDLAYGVF TTDGHDWYQL RQALNQRLLK PAEAALYTDA 

       190        200        210        220        230        240 
LNEVIDSFVV RLDQLRAESA SGDQVPDMAD LLYHFALEAI CYILFEKRIG CLEASIPKDT 

       250        260        270        280        290        300 
ENFIRSVGLM FQNSVYVTFL PKWTRPLLPF WKRYLDGWDT IFSFGKNLID QKLQEVVAQL 

       310        320        330        340        350        360 
QSAGSDGVQV SGYLHSLLTS GQLSPREALG SLPELLLAGV DTTSNTLTWA LYHLSKNPEI 

       370        380        390        400        410        420 
QAALRKEVVG VVAAGQVPQH KDFAHMPLLK AVLKETLRLY PVIPANSRII VDKEIEVGGF 

       430        440        450        460        470        480 
LFPKNTQFVF CHYVTSRDPS TFSEPDTFWP YRWLRKGQPE TSKTQHPFGS VPFGYGVRAC 

       490        500        510        520        530 
LGRRIAELEM QLLLARLIQR YELMLAPETG EVQSVARIVL VPNKKVGLRF LPTQR
P17177 in FASTA format

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