[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1016/0014-5793(93)80297-8; PubMed=8405412 [NCBI, ExPASy, EBI, Israel, Japan] Monstein H.J., Thorup J.U., Folkesson R., Johnsen A.H., Rehfeld J.F.; "cDNA deduced procionin. Structure and expression in protochordates resemble that of procholecystokinin in mammals."; FEBS Lett. 331:60-64(1993).
[2]	PROTEIN SEQUENCE OF 109-116. TISSUE=Neural ganglion; PubMed=2303439 [NCBI, ExPASy, EBI, Israel, Japan] Johnsen A.H., Rehfeld J.F.; "Cionin: a disulfotyrosyl hybrid of cholecystokinin and gastrin from the neural ganglion of the protochordate Ciona intestinalis."; J. Biol. Chem. 265:3054-3058(1990).

Comments

SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in both the gut and the neural ganglion.
SIMILARITY: Belongs to the gastrin/cholecystokinin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X69130; CAA48884.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

S36901; S36901.

NP_001027711.1; -.

3D structure databases

ModBase

P16240.

Ontologies

GO:0007218;	Biological process: neuropeptide signaling pathway (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR015499; CCK.
IPR001651; Gastrin.
IPR013152; Gastrin_CCK_CS.
Graphical view of domain structure.

PANTHER

PTHR10786; CCK; 1.

Pfam

PF00918; Gastrin; 1.
Pfam graphical view of domain structure.

SMART

SM00029; GASTRIN; 1.
SMART graphical view of domain structure.

PS00259; GASTRIN; 1.

Genome annotation databases

GeneID

445737; -.

Phylogenomic databases

HOVERGEN

P16240; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amidation; Cleavage on pair of basic residues; Direct protein sequencing; Hormone; Neuropeptide; Secreted; Signal; Sulfation.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 22`	`22`	`Potential.`
`PROPEP`	`23 108`	`86`		`PRO_0000010671`
`PEPTIDE`	`109 116`	`8`	`Cionin.`	`PRO_0000010672`
`PROPEP`	`120 128`	`9`		`PRO_0000010673`
`MOD_RES`	`110 110`		`Sulfotyrosine.`
`MOD_RES`	`111 111`		`Sulfotyrosine.`
`MOD_RES`	`116 116`		`Phenylalanine amide.`

Sequence information

Length: 128 AA [This is the length of the unprocessed precursor]

Molecular weight: 14820 Da [This is the MW of the unprocessed precursor]

CRC64: BF1DE73438E66609 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGSNIVIYFS IIVIVTLNVN GVPASDLFKS VSQYHIPRSK VINKETVTKP LQFQRAICRL 

        70         80         90        100        110        120 
LQKLGEETFA RLSQSELEAK QLDLIKTCYQ ANSFGDNENQ GHMQRMDRNY YGWMDFGKRA 


IEDVDYEY

P16240 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools