[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Stock 51; DOI=10.1093/nar/18.1.173; PubMed=2308823 [NCBI, ExPASy, EBI, Israel, Japan] Pritchard A.E., Seilhamer J.J., Mahalingam R., Sable C.L., Venuti S.E., Cummings D.J.; "Nucleotide sequence of the mitochondrial genome of Paramecium."; Nucleic Acids Res. 18:173-180(1990).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Stock 51; DOI=10.1016/0378-1119(89)90320-X; PubMed=2670676 [NCBI, ExPASy, EBI, Israel, Japan] Pritchard A.E., Venuti S.E., Ghalambor M.A., Sable C.L., Cummings D.J.; "An unusual region of Paramecium mitochondrial DNA containing chloroplast-like genes."; Gene 78:121-134(1989).

Comments

CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
COFACTOR: Binds 1 4Fe-4S cluster (Potential).
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: Belongs to the complex I 20 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X15917; CAA34045.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M26930; AAA79257.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S07736; F2PPG.

3D structure databases

ModBase

P15602.

Ontologies

GO:0005746;	Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006810;	Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR006138; NADH_DHase_20kDa_su.
IPR014406; NiFe_hyd_3_ssu/Q_oxred_NuoB.
IPR006137; OxRdtase_q6.
Graphical view of domain structure.

PANTHER

PTHR11995:SF2; NADH_DH_20kDa; 1.
PTHR11995; NiFe_hyd_3_ssu/Q_oxred_NuoB; 1.

Pfam

PF01058; Oxidored_q6; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01957; nuoB_fam; 1.

PROSITE

PS01150; COMPLEX1_20K; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

4Fe-4S; Electron transport; Iron; Iron-sulfur; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Respiratory chain; Transport.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 156`	`156`	`NADH-ubiquinone oxidoreductase 20 kDa subunit.`	`PRO_0000118739`
`METAL`	`33 33`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`34 34`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`98 98`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`128 128`		`Iron-sulfur (4Fe-4S) (Potential).`
`CONFLICT`	`123 127`		`MLCPR -> IFVPG (in Ref. 2; AAA79257).`

Sequence information

Length: 156 AA [This is the length of the unprocessed precursor]

Molecular weight: 17454 Da [This is the MW of the unprocessed precursor]

CRC64: B056E34343D75C2F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MILKADFLKL SANNLISWAR QGSFWPLTFG LACCALEMMH ATVSRYDFDR FGVIFRATPR 

        70         80         90        100        110        120 
QADLIIVAGT VTNKMAPALR RLYDQTADPK WVLSMGSCAN GGGYYHYSYA VVKGCDKIIP 

       130        140        150 
VDMLCPRCPP TAEALFFGVL QLQKTLMKTI NEKKVF

P15602 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools