[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=K12;
PubMed=6343085 [NCBI, ExPASy, EBI, Israel, Japan]
Stephens P.E.,
Darlison M.G.,
Lewis H.M.,
Guest J.R.;
"The pyruvate dehydrogenase complex of Escherichia coli K12. Nucleotide sequence encoding the pyruvate dehydrogenase component.";
Eur. J. Biochem. 133:155-162(1983).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1093/nar/22.9.1637; PubMed=8202364 [NCBI, ExPASy, EBI, Israel, Japan]
Fujita N.,
Mori H.,
Yura T.,
Ishihama A.;
"Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region.";
Nucleic Acids Res. 22:1637-1639(1994).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan]
Blattner F.R.,
Plunkett G. III,
Bloch C.A.,
Perna N.T.,
Burland V.,
Riley M.,
Collado-Vides J.,
Glasner J.D.,
Rode C.K.,
Mayhew G.F.,
Gregor J.,
Davis N.W.,
Kirkpatrick H.A.,
Goeden M.A.,
Rose D.J.,
Mau B.,
Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1474(1997).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION TO 145 AND 275.
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi K.,
Morooka N.,
Yamamoto Y.,
Fujita K.,
Isono K.,
Choi S.,
Ohtsubo E.,
Baba T.,
Wanner B.L.,
Mori H.,
Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-23.
STRAIN=K12;
DOI=10.1016/0014-5793(93)81605-Y; PubMed=8262214 [NCBI, ExPASy, EBI, Israel, Japan]
Haydon D.J.,
Quail M.A.,
Guest J.R.;
"A mutation causing constitutive synthesis of the pyruvate dehydrogenase complex in Escherichia coli is located within the pdhR gene.";
FEBS Lett. 336:43-47(1993).
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[6]
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PROTEIN SEQUENCE OF 2-13.
STRAIN=K12 / EMG2;
DOI=10.1002/elps.1150180807; PubMed=9298646 [NCBI, ExPASy, EBI, Israel, Japan]
Link A.J.,
Robison K.,
Church G.M.;
"Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.";
Electrophoresis 18:1259-1313(1997).
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[7]
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ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-716, AND MASS SPECTROMETRY.
DOI=10.1074/mcp.M800187-MCP200; PubMed=18723842 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang J.,
Sprung R.,
Pei J.,
Tan X.,
Kim S.,
Zhu H.,
Liu C.F.,
Grishin N.V.,
Zhao Y.;
"Lysine acetylation is a highly abundant and evolutionarily conserved modification in E. coli.";
Mol. Cell. Proteomics 0:0-0(2008).
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[8]
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X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
DOI=10.1021/bi0118557; PubMed=11955070 [NCBI, ExPASy, EBI, Israel, Japan]
Arjunan P.,
Nemeria N.,
Brunskill A.,
Chandrasekhar K.,
Sax M.,
Yan Y.,
Jordan F.,
Guest J.R.,
Furey W.;
"Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution.";
Biochemistry 41:5213-5221(2002).
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- FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
- CATALYTIC ACTIVITY: Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.
- COFACTOR: Magnesium.
- COFACTOR: Thiamine pyrophosphate.
- SUBUNIT: Homodimer.
- INTERACTION:
P77439:fryA; NbExp=1; IntAct=EBI-542683, EBI-545399;
P46889:ftsK; NbExp=1; IntAct=EBI-542683, EBI-550795;
P0A6F5:groL; NbExp=1; IntAct=EBI-542683, EBI-543750;
P0AEV9:hycI; NbExp=1; IntAct=EBI-542683, EBI-552628;
P0AB83:nth; NbExp=1; IntAct=EBI-542683, EBI-555213;
P0A8N7:poxA; NbExp=1; IntAct=EBI-542683, EBI-562598;
P0AB89:purB; NbExp=1; IntAct=EBI-542683, EBI-556534;
P0AG40:ribF; NbExp=1; IntAct=EBI-542683, EBI-542969;
P05100:tag; NbExp=1; IntAct=EBI-542683, EBI-558722;
P26602:ubiC; NbExp=1; IntAct=EBI-542683, EBI-559360;
P0A9U1:ybhF; NbExp=1; IntAct=EBI-542683, EBI-547696;
P0A8L7:yciU; NbExp=1; IntAct=EBI-542683, EBI-544511;
P76049:ycjY; NbExp=1; IntAct=EBI-542683, EBI-544654;
P76170:ynfB; NbExp=1; IntAct=EBI-542683, EBI-544774;
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