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UniProtKB/Swiss-Prot entry P0A9S6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GLDA_ECOL6
Primary accession number P0A9S6
Secondary accession numbers P32665 P78132
Integrated into Swiss-Prot on July 19, 2005
Sequence was last modified on July 19, 2005 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 26)
Name and origin of the protein
Protein name Glycerol dehydrogenase
Synonyms GLDH
GDH
EC 1.1.1.6
Gene name
Name: gldA
OrderedLocusNames: c4904
From
Escherichia coli O6 [TaxID: 217992] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=O6:H1 / CFT073 / ATCC 700928 / UPEC;
DOI=10.1073/pnas.252529799; PubMed=12471157 [NCBI, ExPASy, EBI, Israel, Japan]
Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R.;
"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli.";
Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE014075; AAN83332.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_756758.2; -.
3D structure databases
HSSP Q9WYQ4; 1KQ3. [HSSP ENTRY / PDB]
ModBase P0A9S6.
Ontologies
GO
GO:0008888; Molecular function: glycerol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006071; Biological process: glycerol metabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001670; Fe_AlcDHase.
IPR016205; Glycerol_DH.
Graphical view of domain structure.
Pfam PF00465; Fe-ADH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000112; Glycerol_dehydrogenase; 1.
PROSITE PS00913; ADH_IRON_1; 1.
PS00060; ADH_IRON_2; 1.
ProtoNet P0A9S6.
Genome annotation databases
GeneID 1040105; -.
GenomeReviews AE014075_GR; c4904.
KEGG ecc:c4904; -.
Phylogenomic databases
HOGENOM P0A9S6; -.
Genome annotation databases
CMR P0A9S6; c4904.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glycerol metabolism; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   367  367     Glycerol dehydrogenase. PRO_0000087829
NP_BIND   94    98  5     NAD (By similarity). 
NP_BIND   116   119  4     NAD (By similarity). 
METAL   171   171        Zinc; catalytic (By similarity). 
METAL   254   254        Zinc; catalytic (By similarity). 
METAL   271   271        Zinc; catalytic (By similarity). 
BINDING   37    37        NAD (By similarity). 
BINDING   121   121        Substrate (By similarity). 
BINDING   125   125        NAD (By similarity). 
BINDING   127   127        NAD; via carbonyl oxygen (By similarity). 
BINDING   131   131        NAD (By similarity). 
BINDING   171   171        Substrate (By similarity). 
BINDING   254   254        Substrate (By similarity). 
BINDING   271   271        Substrate (By similarity). 
Sequence information
Length: 367 AA [This is the length of the unprocessed precursor] Molecular weight: 38712 Da [This is the MW of the unprocessed precursor] CRC64: F6F3F275B4091F28 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDRIIQSPGK YIQGADVINR LGEYLKPLAE RWLVVGDKFV LGFAQSTVEK SFKDAGLVVE 

        70         80         90        100        110        120 
IAPFGGECSQ NEIDRLRGIA ETAQCGAILG IGGGKTLDTA KALAHFMGVP VAIAPTIAST 

       130        140        150        160        170        180 
DAPCSALSVI YTDEGEFDRY LLLPNNPNMV IVDTKIVAGA PARLLAAGIG DALATWFEAR 

       190        200        210        220        230        240 
ACSRSGATTM AGGKCTQAAL ALAELCYNTL LEEGEKAMLA AEQHVVTPAL ERVIEANTYL 

       250        260        270        280        290        300 
SGVGFESGGL AAAHAVHNGL TAIPDAHHYY HGEKVAFGTL TQLVLENAPV EEIETVAALS 

       310        320        330        340        350        360 
HAVGLPITLA QLDIKEDVPA KMRIVAEAAC AEGETIHNMP GGATPDQVYA ALLVADQYGQ 


RFLQEWE
P0A9S6 in FASTA format

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