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UniProtKB/Swiss-Prot entry O46658

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP2DP_PIG
Primary accession number O46658
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 56)
Name and origin of the protein
Protein name Cytochrome P450 2D25
Synonyms EC 1.14.14.-
CYPIID25
Vitamin D(3) 25-hydroxylase
Gene name
Name: CYP2D25
From
Sus scrofa (Pig) [TaxID: 9823] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-57; 249-273 AND 408-430.
TISSUE=Liver;
DOI=10.1006/bbrc.1997.7551; PubMed=9425298 [NCBI, ExPASy, EBI, Israel, Japan]
Postlind H., Axen E., Bergman T., Wikvall K.;
"Cloning, structure, and expression of a cDNA encoding vitamin D3 25-hydroxylase.";
Biochem. Biophys. Res. Commun. 241:491-497(1997).
[2]
 PROTEIN SEQUENCE OF 2-17.
TISSUE=Liver;
PubMed=1445236 [NCBI, ExPASy, EBI, Israel, Japan]
Axen E., Bergman T., Wikvall K.;
"Purification and characterization of a vitamin D3 25-hydroxylase from pig liver microsomes.";
Biochem. J. 287:725-731(1992).
[3]
 PROTEIN SEQUENCE OF 2-11.
TISSUE=Liver;
DOI=10.1016/0167-4838(91)90161-R; PubMed=1859829 [NCBI, ExPASy, EBI, Israel, Japan]
Sono H., Sonoda Y., Sato Y.;
"Purification and characterization of cytochrome P-45014DM (lanosterol 14 alpha-demethylase) from pig liver microsomes.";
Biochim. Biophys. Acta 1078:388-394(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y16417; CAA76205.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JC5819; JC5819.
RefSeq NP_999559.1; -.
UniGene Ssc.55051
3D structure databases
HSSP P00179; 1DT6. [HSSP ENTRY / PDB]
ModBase O46658.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
IPR008069; Cyt_P450_E_grp-I_CYP2D-like.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR01686; EP450ICYP2D.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS O46658.
Genome annotation databases
GeneID 397687; -.
KEGG ssc:397687; -.
Phylogenomic databases
HOVERGEN O46658; -.
Other
ProtoNet O46658.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   500  499     Cytochrome P450 2D25. PRO_0000051745
METAL   446   446        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 500 AA [This is the length of the unprocessed precursor] Molecular weight: 56512 Da [This is the MW of the unprocessed precursor] CRC64: F1C878A02C44503D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGLLTGDLLG ILALAMVIFL LLVDLMHRRS RWAPRYPPGP MPLPGLGNLL QVNFQDPRLS 

        70         80         90        100        110        120 
FIQLRRRFGD VFSLQQIWRP VVVLNGLAAV REALVSHSHE TSDRPPVFIL EHLGYGPRSE 

       130        140        150        160        170        180 
GVILARYGKA WREQRRFSVS TLRNFGLGKK SLEEWVTQEA SCLCAAFADQ AGRPFSPNNL 

       190        200        210        220        230        240 
LNKAVSNVIA SLTFARRFEY NDPRMLKLLD LVLEGLKEEV GLMRQVLEAM PVLRHIPGLC 

       250        260        270        280        290        300 
AKLFPRQKAF LVMIDELITE HKMTRDLAQP PRDLTDAFLD EMKEAKGNPE SSFNDENLRL 

       310        320        330        340        350        360 
VVAHLFSAGM ITTSTTLAWA LLLMILHPDV QRRVQQEIDE VIGHVRQPEI KDQALMPFTL 

       370        380        390        400        410        420 
AVLHEVQRFG DIVPLGVAHM TSCDIEVQGF LIPKGTTLIT NLTSVLKDET VWKKPFRFYP 

       430        440        450        460        470        480 
EHFLDAQGRF TKQEAFMPFS AGRRSCLGEP LARMELFLFF TTLLQAFSFS VPTGQPCPSD 

       490        500 
HGVFAFLLFP SPYQLCAVPR
O46658 in FASTA format

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