NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 50394;
DOI=10.1038/387493a0; PubMed=9168110 [NCBI, ExPASy, EBI, Israel, Japan]
Lang B.F., Burger G., O'Kelly C.J., Cedergren R., Golding G.B., Lemieux C., Sankoff D., Turmel M., Gray M.W.;
"An ancestral mitochondrial DNA resembling a eubacterial genome in miniature.";
Nature 387:493-497(1997).

Comments

FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
CATALYTIC ACTIVITY: NADH + acceptor = NAD⁺ + reduced acceptor.
SUBUNIT: Complex I is composed of about 30 different subunits.
SUBCELLULAR LOCATION: Mitochondrion inner membrane (By similarity). Note=Matrix and cytoplasmic side of the mitochondrial inner membrane (By similarity).
SIMILARITY: Belongs to the complex I 30 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF007261; AAD11898.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S78165; S78165.

RefSeq

NP_044783.1; -.

3D structure databases

ModBase

O21271.

Ontologies

GO:0005746;	Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0008137;	Molecular function: NADH dehydrogenase (ubiquinone) activity (inferred from electronic annotation from InterPro).
GO:0006120;	Biological process: mitochondrial electron transport, NADH to ubiquinone (inferred from electronic annotation from InterPro).
GO:0006810;	Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR010218; NADH_DH_csu.
IPR001268; NADH_DHase_Ub_30kDa_su.
Graphical view of domain structure.

Pfam

PF00329; Complex1_30kDa; 1.
Pfam graphical view of domain structure.

ProDom

PD001581; Complex1_30K; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR01961; NuoC_fam; 1.

PROSITE

PS00542; COMPLEX1_30K; 1.

ProtoNet

O21271.

Genome annotation databases

GeneID

801075; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Respiratory chain; Transport; Ubiquinone.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 204`	`204`		`NADH-ubiquinone oxidoreductase subunit 9.`	`PRO_0000118649`

Sequence information

Length: 204 AA [This is the length of the unprocessed precursor]

Molecular weight: 24239 Da [This is the MW of the unprocessed precursor]

CRC64: 8AA999B21913AEC6 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKKQEQNQFL KEFGISLIKM FPKYIDKAIY SKGELTLHVK PTNLIALMKI LKNHTNCQFK 

        70         80         90        100        110        120 
SLSDLCAVDF PEKKERFEIV YNLLSVRYNS RIRVKTFVDE LTPVPSVTCL FQAAGWFERE 

       130        140        150        160        170        180 
VWDLFGVYFT NHPDLRRILT DYGFEGHPMR KDFPLTGYVE VRYDDEQKRV VTESLEMTQE 

       190        200 
FRSFNFTSPW EQIEISKPNI KEKK

O21271 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools