FUNCTION: Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ (By similarity).
CATALYTIC ACTIVITY: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O₂ = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H₂O₂ + 2 H₂O.
PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis .
SIMILARITY: Belongs to the pqqC family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000680; ABP84728.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001187460.1; -.

3D structure databases

ModBase

A4XTR2.

Ontologies

GO:0033732;	Molecular function: pyrroloquinoline-quinone synthase activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0018189;	Biological process: pyrroloquinoline quinone biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00654; -; 1.
PBIL [Tree]

InterPro

IPR011845; PQQ_synth_PqqC.
IPR004305; TENA/THI4/PQQ_synth_PqqC.
Graphical view of domain structure.

Pfam

PF03070; TENA_THI-4; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02111; PQQ_syn_pqqC; 1.

ProtoNet

A4XTR2.

Genome annotation databases

GeneID

5109858; -.

GenomeReviews

CP000680_GR; Pmen_1967.

KEGG

pmy:Pmen_1967; -.

CMR

A4XTR2; Pmen_1967.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Oxidoreductase; PQQ biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 250`	`250`		`Pyrroloquinoline-quinone synthase.`	`PRO_1000061674`

Sequence information

Length: 250 AA [This is the length of the unprocessed precursor]

Molecular weight: 29097 Da [This is the MW of the unprocessed precursor]

CRC64: 468A0FD2B4DCF771 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSQAAMTPAE FEQALRAKGA LYHIHHPFHR AMYEGRATRE QIQGWVANRF YYQVNIPLKD 

        70         80         90        100        110        120 
AAILANCPDR ETRREWIQRI LDHDGAPGEE GGIEAWLRLA ESVGLDREQV LSQELVLPGV 

       130        140        150        160        170        180 
RFAVDAYVNF ARRASWQEAA SSSLTELFAP TIHQSRLDAW PQHYPWIDAA GYDYFRNRLS 

       190        200        210        220        230        240 
QARRDVEHGL RITLEHYRTR DAQEHMLNIL QFKLDVLWSM LDAMSMAYEL ERPPYHTVTA 

       250 
ERVWHKGIDL

A4XTR2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools