| Official Name |
|---|
| Delta(4)-3-oxosteroid 5-beta-reductase.
|
| Alternative Name(s) |
|---|
| 3-oxo-Delta(4)-steroid 5-beta-reductase. |
| 5-beta-reductase. |
| Androstenedione 5-beta-reductase. |
| Cholestenone 5-beta-reductase. |
| Cortisone 5-beta-reductase. |
| Cortisone beta-reductase. |
| Cortisone Delta(4)-5-beta-reductase. |
| Delta(4)-3-ketosteroid 5-beta-reductase. |
| Delta(4)-5-beta-reductase. |
| Delta(4)-hydrogenase. |
| Steroid 5-beta-reductase. |
| Testosterone 5-beta-reductase. |
| Reaction catalysed |
|---|
- 5-beta-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + NADPH
- 17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP(+) <=> cortisone + NADPH
|
| Comment(s) |
|---|
- The enzyme from human efficiently catalyzes the reduction of
progesterone, androstenedione, 17-alpha-hydroxyprogesterone and
testosterone to 5-beta-reduced metabolites; it can also act on
aldosterone, corticosterone and cortisol, but to a lesser extent.
- The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-
one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
|
| Cross-references |
|---|
| Biochemical Pathways; map number(s) | J9 |
| PROSITE | PDOC00061 |
| BRENDA | 1.3.1.3 |
| PUMA2 | 1.3.1.3 |
| PRIAM enzyme-specific profiles | 1.3.1.3 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.3.1.3 |
| IUBMB Enzyme Nomenclature | 1.3.1.3 |
| IntEnz | 1.3.1.3 |
| MEDLINE | Find literature relating to 1.3.1.3 |
| MetaCyc | 1.3.1.3 |
| UniProtKB/Swiss-Prot |
|
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