| Official Name |
|---|
| Methylmalonate-semialdehyde dehydrogenase (acylating).
|
| Alternative Name(s) |
|---|
| MMSA dehydrogenase. |
| MSDH. |
| Reaction catalysed |
|---|
| 2-methyl-3-oxopropanoate + CoA + H(2)O + NAD(+) <=> propanoyl-CoA + HCO(3)(-) + NADH |
| Comment(s) |
|---|
- Also converts 3-oxopropanoate into acetyl-CoA.
- The reaction occurs in two steps with the decarboxylation process
preceding CoA-binding.
- Bicarbonate rather than CO(2) is released as a final product.
|
| Cross-references |
|---|
| Biochemical Pathways; map number(s) | C9 |
| PROSITE | PDOC00068 |
| BRENDA | 1.2.1.27 |
| PUMA2 | 1.2.1.27 |
| PRIAM enzyme-specific profiles | 1.2.1.27 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.2.1.27 |
| IUBMB Enzyme Nomenclature | 1.2.1.27 |
| IntEnz | 1.2.1.27 |
| MEDLINE | Find literature relating to 1.2.1.27 |
| MetaCyc | 1.2.1.27 |
| UniProtKB/Swiss-Prot |
| P42412, IOLA_BACSU; | Q17M80, MMSA_AEDAE; | Q7QC84, MMSA_ANOGA; |
| Q0WM29, MMSA_ARATH; | Q07536, MMSA_BOVIN; | P52713, MMSA_CAEEL; |
| Q54I10, MMSA_DICDI; | Q7KW39, MMSA_DROME; | Q29HB2, MMSA_DROPS; |
| Q02252, MMSA_HUMAN; | Q9EQ20, MMSA_MOUSE; | P28810, MMSA_PSEAE; |
| Q02253, MMSA_RAT; |
|
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